Diabetologia

, Volume 39, Issue 9, pp 1063–1069

Epidemiology of childhood IDDM in Northern Ireland 1989–1994: Low incidence in areas with highest population density and most household crowding

  • C. C. Patterson
  • D. J. Carson
  • D. R. Hadden
  • The Northern Ireland Diabetes Study Group
Originals

Summary

During the period 1989–1994, 462 cases of insulin-dependent diabetes mellitus were registered among children from Northern Ireland aged under 15 years. The estimated completeness of the register was 98.8% (95% confidence interval (CI) 97.7%, 99.9%). A standardised rate of 19.6 (95% CI 17.8, 21.4) per 100 000 person years was obtained, placing Northern Ireland near the top of the range of published incidence in the United Kingdom, with a rate close to that reported for Scotland. In an analysis based on 217 postcode sectors, areas with a high population density and the most material deprivation were observed to have the lowest incidence rates. After inclusion of population density in a Poisson regression analysis, the component of deprivation which was found to be most significant was household crowding. Relative to children living in areas of low population density, there was a reduced risk for children in medium (relative incidence 0.85 (95% confidence limits CI 0.67,1.09)) and high (0.62 (95% CI 0.48,0.80)) population density areas. Similarly, relative to children living in areas with low levels of household crowding, there was a reduced risk for children in medium (relative incidence 0.73 (95% CI 0.58,0.93)) and high (0.67 (95%CI 0.53,0.83)) levels of household crowding. Tests for space-time clustering at diagnosis and at birth were negative. A possible explanation for the differences in incidence rate observed in this study is that exposure to infections very early in childhood is a protective factor. Later infections may act as either initiators or promoters of diabetes, but the absence of space-time clustering suggests that no single specific infectious agent is responsible.

Keywords

Type 1 (insulin-dependent) diabetes mellitus epidemiology incidence childhood population density material deprivation overcrowding space-time clustering 

Abbreviations

IDDM

Insulin-dependent diabetes mellitus

CI

confidence interval

SIR

standardised incidence ratio

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • C. C. Patterson
    • 1
  • D. J. Carson
    • 2
  • D. R. Hadden
    • 3
  • The Northern Ireland Diabetes Study Group
  1. 1.Department of Epidemiology and Public HealthThe Queen's University of Belfast, Royal Victoria HospitalBelfastUK
  2. 2.Department of Child HealthThe Queen's University of BelfastBelfastNorthern Ireland, UK
  3. 3.Sir George E. Clark Metabolic UnitRoyal Victoria HospitalBelfastNorthern Ireland, UK

Personalised recommendations