Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Insulin analogues and carcinoma of the breast

This is a preview of subscription content, log in to check access.


  1. 1.

    Nielsen FS, Jorgensen LN, Ipsen M, Voldsgaard AI, Parving H-H (1995) Long-term comparison of human insulin analogue B10Asp and soluble human insulin in IDDM patients on a basal/bolus insulin regimen. Diabetologia 38: 592–598

  2. 2.

    Drejer K (1992) The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab Rev 8: 259–286

  3. 3.

    LeRoith D, Werner H, Beitner-Johnson D, Roberts CTJ (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 16: 143–163

  4. 4.

    Ebeling P, Koivisto VA (1994) Physiological importance of dehydroepiandrosterone. Lancet 343: 1479–1481

  5. 5.

    Valadares JRE, Singhal RL, Parulekar MR (1968) 17Β-estradiol: inducer of uterine hexokinase. Science 159: 990–991

  6. 6.

    Singhal RL, Valadares JRE, Ling GM (1969) Estrogenic regulation of uterine carbohydrate metabolism during senescence. Am J Physiol 217: 793–797

  7. 7.

    Martikainen H, Koistinen R, SeppÄlÄ M (1992) The effect of estrogen level on glucose-induced changes in serum insulin-like growth factor binding protein-1 concentration. Fertil Steril 58: 543–546

  8. 8.

    Manni A, Wright C, Buck H (1991) Growth factor involvement in the multihormonal regulation of MCF-7 breast cancer cell growth in soft agar. Breast Cancer Res Treat 20: 43–52

  9. 9.

    Huynh H, Pollak M (1994) Enhancement of tamoxifen-induced suppression of insulin-like growth factor I gene expression and serum level by a somatostatin analogue. Biochem Biophys Res Commun 203: 253–259

  10. 10.

    Weckbecker G, Liu R, Tolcsvai L, Burns C (1992) Antiproliferative effects of the somatostatin analogue octreotide (SMS 201-995) on ZR-75-1 human breast cancer cells in vivo and in vitro. Cancer Res 52: 4973–4978

  11. 11.

    Ramalingam V, Krishnamoorthy G, Govindarajulu P (1994) Enzymes of carbohydrate metabolism in human breast carcinoma: relationship with serum hormones. Neoplasma 41: 49–54

  12. 12.

    Yamamoto H, Aikawa T, Matsutaka H, Okuda T, Ishikawa E (1974) Interorgan relationships of amino acid metabolism in fed rats. Am J Physiol 226: 1428–1433

  13. 13.

    Falholt K, Cutfield R, Alejandro R, Voelund A, Heding LG, Mintz DH (1991) Influence of portal delivery of insulin on intracellular glucose and lipid metabolism. Metabolism 40: 122–126

  14. 14.

    Raineri R, Levy HR (1970) On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase. Biochemistry 9: 2233–2243

  15. 15.

    Farquharson C, Milne J, Loveridge N (1993) Mitogenic action of insulin-like growth factor-I on human osteosarcoma MG-63 cells and rat osteoblasts maintained in situ: the role of glucose-6-phosphate dehydrogenase. Bone Miner 22: 105–115

Download references

Author information

Correspondence to Dr. P. Ebeling.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ebeling, P. Insulin analogues and carcinoma of the breast. Diabetologia 39, 124–125 (1996).

Download citation


  • Public Health
  • Carcinoma
  • Internal Medicine
  • Human Physiology
  • Metabolic Disease