Diabetologia

, Volume 36, Issue 3, pp 234–238

HLA-associated susceptibility to Type 2 (non-insulin-dependent) diabetes mellitus: the Wadena City Health Study

  • S. S. Rich
  • L. R. French
  • J. M. Sprafka
  • J. P. Clements
  • F. C. Goetz
Originals

Summary

Epidemiologic data suggest that a parental history of Type 2 (non-insulin-dependent) diabetes mellitus increases the risk of Type 1 (insulin-dependent) diabetes in siblings of a Type 1 diabetes proband. This increase in risk is consistent with a shared genetic susceptibility between Type 1 and Type 2 diabetes. We have previously reported evidence that HLA-DR4-linked factors may represent a homogeneous subset of diabetes susceptibility. First, HLA-DR4 frequency was higher in Type 1 diabetic study subjects with a Type 2 diabetic parent than in Type 1 diabetic subjects whose parents were not diabetic. Second, a DR4-haplotype was transmitted from the Type 2 diabetic parent to the Type 1 offspring more often than expected. These data are consistent with the hypothesis that families with a Type 2 diabetic parent and Type 1 diabetic child, heavily determined by HLA-DR4 linked factors, may represent a homogeneous subset of diabetes susceptibility. In this report, we further explore the relationship between the high-risk HLA antigen (HLA-DR4) in study subjects with differing glycaemic status (National Diabetes Data Group criteria). In this community-based study, we find evidence that HLA-DR4 is increased in study subjects with Type 2 diabetes and may be a marker for Type 2 diabetes susceptibility.

Key words

Genetics Type 2 (non-insulin-dependent) diabetes mellitus HLA 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • S. S. Rich
    • 1
  • L. R. French
    • 2
  • J. M. Sprafka
    • 3
  • J. P. Clements
    • 2
  • F. C. Goetz
    • 4
  1. 1.Department of Laboratory Medicine and Pathology and Institute of Human GeneticsUniversity of MinnesotaMinneapolisUSA
  2. 2.Chronic Disease and Environmental Epidemiology Section, Minnesota Department of HealthUniversity of MinnesotaMinneapolisUSA
  3. 3.Division of EpidemiologyUniversity of MinnesotaMinneapolisUSA
  4. 4.Department of MedicineUniversity of MinnesotaMinneapolisUSA

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