Neuron-specific enolase (NSE) was measured in serum samples of 35 patients with small cell lung cancer and 10 control patients. The samples were collected during 10 days after the first course of chemotherapy, in order to investigate whether changes of NSE had a predictive value for tumour response. Three patterns of change of NSE were observed. Pattern 1 showed an increase of serum NSE with a maximum value more than 1.5 times the pretreatment level (n=17); pattern 2 involved no increase at all or less than 1.5 times the pretreatment level (n=14); pattern 3 showed a continuous decrease (n=5). No relationship between the three patterns of change and the tumour response was observed. Only an NSE level <10 ng/ml at the time of start of the second course predicted a major response.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Akoun GM, Scarna HM, Milleron BJ, Bénichou MP, Herman DP (1985) Serum neuron-specific enolase. A marker for disease extent and response to therapy for small cell lung cancer. Chest 87:39–43
Ariyoshi Y, Kato K, Ueda R, Takaheshi T, Sato T, Akatsuka H, Kuwabara M, Kito K, Suchi T, Nishimura M et al. (1986) Biological and clinical implication of neuron-specific enolase and creatine kinase BB in small cell lung cancer. Jpn J Clin Oncol 16:213–221
Bork E, Hansen M, Urdal P, Paus E, Holst JJ, Schifter S, Fenger M, Engbaek F (1988) Early detection of response in small cell bronchogenic carcinoma by changes in serum concentrations of creatine kinase, neuron specific enolase, calcitonin, ACTH, serotonin and gastrin releasing peptide. Eur J Cancer Clin Oncol 24:1033–1038
Carney DN, Ihde DC, Cohen MC et al. (1982) Serum neuron-specific enolase: a marker for disease extent and response to therapy of small cell lung cancer. Lancet I:583–585
Cooper EH, Splinter TAW, Brown DA, Muers MF, Peake MD, Pearson SC (1985) Evaluation of a radioimmunoassay for neuron-specific enolase in small cell lung cancer. Br J Cancer 52:333–338
Splinter TAW, Cooper EH, Kho GS, Oosterom R, Peake MD (1987) Neuron-specific enolase as a guide to the treatment of small cell lung cancer. Eur J Cancer Clin Oncol 23:171–176
Reeve JG, Stewart J, Watson JV, Wulfrank D, Twentyman PR, Bleehen NM (1986) Neuron specific enolase expression in carcinoma of the lung. Br J Cancer 53:519–528
WHO (1979) Handbook, for Reporting Results of Cancer Treatment. WHO Offset Publication no. 48
About this article
Cite this article
Splinter, T.A.W., Carney, D.N., Teeling, M. et al. Levels of neuron-specific enolase after chemotherapy do not predict a response in small cell lung cancer. J Cancer Res Clin Oncol 114, 641–643 (1988). https://doi.org/10.1007/BF00398191
- NSE release
- Tumour response
- Small cell lung cancer