Biologic monitoring of workers exposed to silver

  • G. D. DiVincenzo
  • C. J. Giordano
  • L. S. Schriever
Review Articles

Summary

The smelting and refining of silver and the preparation of silver salts for use in photosensitized products can lead to occupational exposures to silver. Our objectives in this study were to determine the absorption and elimination of silver by workers exposed to different species of silver, to estimate the body burden of silver and to relate these findings to the potential development of argyria. Workers potentially exposed to silver (n = 37) and a similar number of controls (n = 35) participated in this study. Blood, urine, feces and hair samples were collected and were analyzed for total silver content by atomic absorption spectroscopy. The mean concentration of silver in the blood, urine and feces of silver workers was 0.011 μg/ml, < 0.005 μg/g and 15 μg/g, respectively; and of controls was < 0.005 μg/ml, < 0.005 μg/g and 1.5 μg/g, respectively. The concentration of silver in hair was markedly higher for the silver workers than for controls (130 ± 160 vs 0.57 ± 0.56 μg/g, respectively). The importance of these latter findings was questionable since airborne particles of silver can bind to hair and lead to apparent high values. Since silver is eliminated predominantly in the feces, fecal measurements were used as an index of exposure and as a means of calculating body burdens. Human exposure to metallic silver at the TLV (0.1 mg/m3) is expected to lead to a fecal excretion of about 1 mg of silver per day. Silver workers excreted an average of 0.3 mg of silver per day in feces, corresponding to a time weighted average workplace exposure of about 0.03 mg/m3. The incremental body burden of silver for silver workers and controls (the latter was derived entirely from food consumption) was calculated to be 14 and 2 μg/kg of body weight, respectively. Our findings indicate that generalized argyria is unlikely to occur in workers exposed to silver at the above exposure levels.

Key words

Silver Occupational exposure Biologic monitoring 

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References

  1. ACGIH (1981) Documentation of the threshold limit values, 4th edn. Cincinnati, Ohio ACGIH (1983) Threshold limit values for chemical substances and physical agents in the workroom environment with intended changes for 1983. Cincinnati, OhioGoogle Scholar
  2. Browning E (1969) Toxicity of industrial metals. Butterworths, London, pp 296–301Google Scholar
  3. Furchner JE, Richmond CR, Drake GA (1968) Comparative metabolism of radionuclides in mammals-IV. Retention of silver 110m in the mouse, rat, monkey and dog. Health Physics 15:505–514Google Scholar
  4. Gafafer WM (1964) Occupational diseases, a guide to their recognition. US Dept of Health, Education and Welfare, Public Health Service, Washington, DCGoogle Scholar
  5. Hamilton A, Hardy HL (1974) Industrial toxicology, 3rd edn. Publishing Sciences Group, Inc, Acton, MA, pp 171–172Google Scholar
  6. Hill WR, Pillsbury DM (1939) Argyria, the pharmacology of silver. The Williams and Wilkins Company, BaltimoreGoogle Scholar
  7. Iyengar GV, Kollmer WE, Bowen HJM (1978) The elemental composition of human tissues and body fluids. Verlag Chemie, New York, p 51Google Scholar
  8. Kehoe RA, Cholak J, Story RV (1940) Manganese, lead, copper and silver in biological materials. J Nutr 20:85–98Google Scholar
  9. Klaassen CD (1979) Biliary excretion of silver in the rat, rabbit and dog. Toxicol Appl Pharmacol 50:49–565Google Scholar
  10. Moss AP, Sugar A, Hayett NA, Atkin A, Wolkstein M, Rosemann KD (1979) The ocular manifestations and functional effects of occupational argyrosis. Arch Ophthalmol 97:906–908Google Scholar
  11. Owens CJ, Yarbrough DR, Brackett NC (1974) Metabolic syndrome following topically applied sulfadiazine silver therapy. Arch Int Med 134:332–335Google Scholar
  12. Roseman KD, Moss A, Kon S (1979) Argyria: clinical implications of exposure to silver nitrate and silver oxide. J Occup Med 21:430Google Scholar
  13. Scott KG, Hamilton JG (1950) The metabolism of silver in the rat with radiosilver used as an indicator. University of California [Berkeley] Publ Pharmacol 2:241–262Google Scholar
  14. Scott KG, Hamilton JG (1948) The metabolism of silver. J Clin Invest 27:555–556Google Scholar
  15. Snyder WS, Cook MJ, Nasset ES, Karhausen LR, Howells GP, Tipton IH (1975) Report of the task group of reference man. Pergamon Press, OxfordGoogle Scholar
  16. Takeuchi T, Hayashi T, Takada J, Koyama W, Hayashi Y (1978) Survey of the trace elements in hairs of the normal Japanese. Ann Rep Res Reactor Inst Kyoto University 4:177–185Google Scholar
  17. Zech P, Colon S, Labeeuw R, Blanc-Brunat N, Richard P, Perol M (1973) Nephrotic syndrome with silver deposits in the glomerular basement membranes during argyria. Nouv Presse Med 2:161–164Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • G. D. DiVincenzo
    • 1
  • C. J. Giordano
    • 1
  • L. S. Schriever
    • 1
  1. 1.Metabolism Group, Toxicological Sciences, Health and Environment Laboratories, and The Industrial LaboratoryEastman Kodak CompanyRochesterUSA

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