G6PD Vientiane: A new glucose-6-phosphate dehydrogenase variant with increased stability
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A new G6PD variant, called G6PD Vientiane, has been discovered in a patient from Laos.
The characteristics of this variant are: mild enzyme deficiency (about 50% of the normal activity) in the granulocytes and the red cells, with normal G6PD-related antigen concentration; increased stability; normal Km glucose 6-phosphate and NADP+; increased inhibition constant by NADPH; decreased inhibition by ATP; slightly increased utilization of the substrate analogue; abnormal pH curve, with maximum activity at pH 9.5; slightly reduced starch gel electrophoretic migration. The implications of the molecular stability of a deficient mutant variant are discussed.
KeywordsStarch NADPH Maximum Activity NADP Inhibition Constant
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