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Human Genetics

, Volume 43, Issue 1, pp 85–89 | Cite as

G6PD Vientiane: A new glucose-6-phosphate dehydrogenase variant with increased stability

  • A. Kahn
  • M. L. North
  • D. Cottreau
  • G. Giron
  • J. M. Lang
  • F. Oberling
Short Communications

Summary

A new G6PD variant, called G6PD Vientiane, has been discovered in a patient from Laos.

The characteristics of this variant are: mild enzyme deficiency (about 50% of the normal activity) in the granulocytes and the red cells, with normal G6PD-related antigen concentration; increased stability; normal Km glucose 6-phosphate and NADP+; increased inhibition constant by NADPH; decreased inhibition by ATP; slightly increased utilization of the substrate analogue; abnormal pH curve, with maximum activity at pH 9.5; slightly reduced starch gel electrophoretic migration. The implications of the molecular stability of a deficient mutant variant are discussed.

Keywords

Starch NADPH Maximum Activity NADP Inhibition Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • A. Kahn
    • 1
  • M. L. North
    • 2
  • D. Cottreau
    • 1
  • G. Giron
    • 3
  • J. M. Lang
    • 3
  • F. Oberling
    • 3
  1. 1.Institut de Pathologie MoléculaireU. 129 de l'INSERMParis, Cédex 14France
  2. 2.Centre de Transfusion SanguineStrasbourgFrance
  3. 3.Clinique des Maladies du SangCentre Hospitalier UniversitaireStrasbourgFrance

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