Veterinary Research Communications

, Volume 12, Issue 1, pp 77–86 | Cite as

Haematology and serum biochemistry in the racing greyhound following intraperitoneal povidone-iodine

  • J. Ndikuwera
  • E. W. Winstanley
  • G. Binta-Mushi
  • E. Z. Mushi
Research Article
Accepted:

Abstract

Povidone-iodine caused peritonitis with neutrophilic leukocytosis and a minimal left shift at the dosage rate of 3.5 ml/kg body weight. A dosage rate of 2 ml/kg only caused slight neutrophilic leukocytosis. There was a significant increase in the levels of creatinine (p=0.049) and BUN (p=0.020) in dogs that received the higher dose rate. Two dogs died from povidone-iodine toxicity with a marked increase in ALT, AP, SDH and conjugated bilirubin. It is concluded that povidone-iodine is unsafe for use in the peritoneal cavity of dogs.

Keywords

Public Health Body Weight Creatinine Bilirubin Peritonitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. AhrenholzD. H. & SimmonsR. L., 1979. Povidone-iodine in peritonitis: adverse effects of local instillation in experimental E. coli peritonits. J. Surg. Res., 26, 458–463Google Scholar
  2. Anon, 1979. Peritonitis. Comp. Cont. Ed., 1, 295Google Scholar
  3. AronoffG. R., FeldmanS. J., DoedensD. J. & LavelleK. J., 1980. Increased serum iodide concentration from iodine absorption through wounds treated topically with povidone-iodine. Am. J. Med. Sci., 279, 173–176Google Scholar
  4. BenjaminM., 1978. Outline of veterinary clinical pathology. 3rd edition. (Iowa University Press, Ames, Iowa)Google Scholar
  5. BerkelmanR. L., HollandB. W. & AndersonR. L., 1982. Increased bactericidal activity of dilute preparations of povidone-iodine solution. J. Clin. Microbiol., 15, 635–639Google Scholar
  6. BoltonJ. S., BornsideG. H. & CohnI., 1979. Intraperitoneal povidone-iodine in experimental canine and murine peritonitis. Am. J. Surg., 137, 780–785Google Scholar
  7. ChesterD. K., 1979. Superficial fungal infections of the skin. Comp. Cont. Ed., 12, 910–916Google Scholar
  8. DineenP., 1978. Hand-washing degerming: a comparison of povidone-iodine and chlorhexidine. Clin. Pharm. Ther., 23, 63–67Google Scholar
  9. FincoD. R., 1980. Kidney function. In: J. J.Kaneko (ed), Clinical biochemistry of domestic animals. 3rd edn. (Academic Press, New York), 337–400Google Scholar
  10. FlintL. M., BeasleyD. J., RichardsonJ. D. & PolkJrH. C., 1979. Topical povidone-iodine reduces mortality from bacterial peritonitis. J. Surg. Res., 26, 280–284Google Scholar
  11. GilmoreO. J. A., 1977. A reappraisal of the use of antiseptics in surgical practice. Ann. R. Coll. Surg. Engl., 59, 93–103Google Scholar
  12. GilmoreO. J. A., MartinT. D. M. & FletcherB. W., 1973. Prevention of wound infection after appendicectomy. Lancet, 1, 220–222Google Scholar
  13. GilmoreO. J. A., ReidC., HouangE. & ShawE. J., 1978a. Intraoperative povidone-iodine in peritonitis. J. Surg. Res., 25, 471–476Google Scholar
  14. GilmoreO. J. A., ReidC., HouangE. T. & ShawE. J., 1978b. Prophylactic povidone-iodine in alimentary surgery. Am. J. Surg., 135, 156–159Google Scholar
  15. GrierR. L., 1976. Intraperitoneal antisepsis and treatment of peritonitis. Arch. Off. J. Am. Vet. Surg., 5, 10–12Google Scholar
  16. IhrkeP. J., 1980. Topical therapy-specific topical pharmacologic agents: dermatologic therapy (part II). Comp. Cont. Ed., 2, 156–164Google Scholar
  17. KingI. R. & DiddleA. W., 1970. Protein-bound iodine and T4 test after vaginal application of povidone-iodine. Am. J. Obstet. Gynecol. 108, 1175–1179Google Scholar
  18. KockM. D., 1979. Peritonitis. Comp. Cont. Ed., 1, 295–303Google Scholar
  19. LaceyR. W., 1979. Antibacterial activity of povidone-iodine against non-sporing bacteria. J. Appl. Bacteriol. 46, 443–449Google Scholar
  20. LagardeM. C., BoltonJ. S. & CohnI., 1978. Intraperitoneal povidone-iodine in experimental peritonits. Ann. Surg., 187, 613–619Google Scholar
  21. LavelleK. J., DoedensD. J., KleitS. A. & ForneyR. B., 1975. Toxicity of sodium iodide in the rabbit: effects on hydrogen ion homeostasis, hepatic and renal functions. Toxicol. Appl. Pharm., 33, 52–61Google Scholar
  22. LavigneJ. E., BrownC. S., MachiedoG. W., BlackwoodJ. M. & RushB. F., 1974. The treatment of experimental peritonitis with intraperitoneal betadine solution. J. Surg. Res., 16, 307–311Google Scholar
  23. LoresM. E., OrtizJ. R. & RoselloP., 1981. Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis. Surg. Gynecol. Obstet 153, 33–38Google Scholar
  24. McAvincheyD. J., McCollumR. T., McElearneyN. G., MundingerG.Jr. & LynchC., 1983. Antiseptics in the treatment of bacterial peritonitis in rats. Brit. J. Surg. 70, 158–160Google Scholar
  25. PietschJ. & MeakinsJ. L., 1976. Complications of povidone-iodine absorption in topically treated burn patients. Lancet, 1, 280–282Google Scholar
  26. PyatiS. P., RamamurthyR. S., KraussM. T. & PildesR. S., 1977. Absorption of iodine in the neonate following topical use of povidone-iodine. J. Paediatr., 91, 825–828Google Scholar
  27. SiggiaS., 1957. The chemistry of polyvinylpyrrolidone iodine. J. Am. Pharm. Assoc., 46, 201–204Google Scholar
  28. SindelarW. F. & MasonG. R. 1979. Irrigation of subcutaneous tissue with povidone-iodine solution for prevention of surgical wound infections. Surg. Gynecol. Obstet., 148, 227–231Google Scholar
  29. StrifeC. F., UhlM., MorrisD. & FallonG., 1977. Peritoneal absorption of povidone-iodine. Lancet 1, 1265Google Scholar
  30. WebsterS. H., RiceM. E., HighmanB. & VonOettingenW. F., 1957. The toxicology of potassium and sodium iodates: acute toxicity in mice. J. Pharm. Exptal. Ther., 120, 171–178Google Scholar
  31. WithrowS. J. & BlackA. P., 1979. Generalized peritonitis in small animals. Vet. Clin. N. Am., 9, 363–379Google Scholar

Copyright information

© Geo Abstracts Ltd 1988

Authors and Affiliations

  • J. Ndikuwera
    • 1
  • E. W. Winstanley
    • 2
  • G. Binta-Mushi
    • 1
  • E. Z. Mushi
    • 1
  1. 1.Faculty of Veterinary ScienceUniversity of ZimbabweHarareZimbabwe
  2. 2.Faculty of Veterinary MedicineUniversity College DublinDublin 4Ireland

Personalised recommendations