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Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart

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Streptozotocin-induced diabetes rsulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.


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Nerurkar, M.A., Satav, J.G. & Katyare, S.S. Insulin-dependent changes in lysosomal cathepsin D activity in rat liver, kidney, brain and heart. Diabetologia 31, 119–122 (1988).

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Key words

  • Streptozotocin
  • diabetes
  • insulin treatment
  • cathepsin D activity