Diabetologia

, Volume 31, Issue 2, pp 71–75 | Cite as

Is insulin atherogenic?

  • R. J. Jarrett
Editorial

References

  1. 1.
    Stout RW (1987) Insulin and atheroma — an update. Lancet I: 1077–1079Google Scholar
  2. 2.
    Vallance-Owen J, Ashton WL (1963) Cardiac infarction and insulin antagonism. Lancet 1: 1226–1228Google Scholar
  3. 3.
    Peters N, Hales CN (1965) Plasma-insulin concentrations after myocardial infarction. Lancet 1: 1144–1145Google Scholar
  4. 4.
    Nikkila EA, Miettinen TA, Vessene MR, Pelkonen R (1965) Plasma-insulin in coronary heart disease: response to oral and intravenous glucose and to tolbutamide. Lancet II: 508–511Google Scholar
  5. 5.
    Tzagournis M, Chiles R, Ryan JM, Skillman TG (1968) Interrelationships of hyperinsulinism and hypertriglyceridemia in young patients in coronary heart disease. Circulation 38: 1156–1163Google Scholar
  6. 6.
    Malherbe C, de Gasparo M, Berthet P, de Hertogh R, Hoet JJ (1970) The pattern of plasma insulin responses to glucose in patients with a previous myocardial infarction — the respective effects of age and disease. Eur J Clin Invest 1: 265–270Google Scholar
  7. 7.
    Gertler MM, Leetma HE, Saluste E, Covalt DA, Rosenberger JL (1972) Covert diabetes mellitus in ischaemic heart and cerebrovascular disease. Geriatrics 27: 105–120Google Scholar
  8. 8.
    Welborn TA, Breckenridge A, Rubinstein AH, Dollery CT, Russell Fraser T (1966) Serum-insulin in essential hypertension and in peripheral vascular disease. Lancet 1: 1336–1337Google Scholar
  9. 9.
    Stout RW (1979) Diabetes and atherosclerosis — the role of insulin. Diabetologia 16: 141–50Google Scholar
  10. 10.
    Ducimetiere P, Eschwege E, Richard J, Rosselin G, Claude JR (1982) Clinical complications of coronary heart disease according to plasma insulin and glucose levels. A further analysis of the Paris Prospective Study. In: Eschwege E (ed) Advances in diabetes epidemiology, INSERM Symposium No. 22. Elsevier, Amsterdam, pp 149–155Google Scholar
  11. 11.
    Pyörälä K, Savolainen E, Kaukola S, Haapakoski J (1982) High plasma insulin as a coronary heart disease risk factor. In: Eschwege E (ed) Advances in diabetes epidemiology, INSERM Symposium No. 22. Elsevier, Amsterdam, pp 143–148Google Scholar
  12. 12.
    Welborn TA, Wearne K (1979) Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentration. Diabetes Care 2: 154–160Google Scholar
  13. 13.
    Eschwege E, Richard JL, Thibult N, Ducimetiere P, Warnet JM, Claude JR, Rosselin GE (1985) Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels: the Paris Prospective study, ten years later. Horm Metab Res [Suppl 15]: 41–46Google Scholar
  14. 14.
    Vandenbroucke JP (1987) Should we abandon statistical modelling altogether? Am J Epidemiol 126: 10–13Google Scholar
  15. 15.
    Cambien F, Chretien JM, Ducimetiere P, Guize L, Richard JL (1985) Is the relationship between blood pressure and cardiovascular risk dependent on body mass index? Am J Epidemiol 122: 434–442Google Scholar
  16. 16.
    Cullen K, Stenhouse NS, Wearne KL, Welborn TA (1983) Multiple regression analysis of risk factors for cardiovascular disease and cancer mortality in Busselton, Western Australia — 13 year study. J Chronic Dis 36: 371–377Google Scholar
  17. 17.
    Pocock SJ, Shaper AG, Phillips AN, Walker M, Whitehead TP (1986) High density lipoprotein cholesterol is not a major risk factor for ischaemic heart disease in British men. Br Med J 292: 515–519Google Scholar
  18. 18.
    Stalder M, Pometta D, Suenram A (1981) Relationship between plasma insulin levels and high density lipoprotein cholesterol levels in healthy men. Diabetologia 21: 544–548Google Scholar
  19. 19.
    Garcia-Webb P, Bonser AM, Whiting D, Masarei JRL (1983) Insulin resistance — a risk factor for coronary heart disease? Scand J Clin Lab Invest 43: 677–685Google Scholar
  20. 20.
    Laakso M, Pyörälä K, Voutilainen E, Marniemi J (1987) Plasma insulin and serum lipids and lipoproteins in middle-aged non-insulin-dependent diabetic and non-diabetic subjects. Am J Epidemiol 125: 611–621Google Scholar
  21. 21.
    Hornick CA, Fellmeth BD (1981) High density lipoprotein cholesterol, insulin and obesity in Samoans. Atherosclerosis 39: 321–328Google Scholar
  22. 22.
    Burke GL, Webber LS, Srinavasan SR, Radhakrishamurthy B, Freedman DS, Berenson GS (1986) Fasting plasma glucose and insulin levels and their relationship to cardiovascular risk factors in children: Bogalusa heart study. Metabolism 35: 441–446Google Scholar
  23. 23.
    Jarrett RJ, McCartney P, Keen H (1982) The Bedford survey. Ten year mortality rates in newly diagnosed diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia 22: 79–84Google Scholar
  24. 24.
    Janka HU, Ziegler AG, Standl E, Mehnert H (1987) Daily insulin dose as a predictor of macrovascular disease in insulin treated non-insulin-dependent diabetics. Diab Metab 13: 359–364Google Scholar
  25. 25.
    Hockaday TDR (1987) Serum insulin concentrations and anticipatory factors of cardiomyopathy in NIDDM. Diab Metab 13: 354–358Google Scholar
  26. 26.
    Knatterud GL, Klimt CR, Levin ME, Jacobson ME, Goldner MG (1978) Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes VII. Mortality and selected nonfatal events with insulin treatment. JAMA 240: 37–42Google Scholar
  27. 27.
    Pyörälä K, Uusitupa M, Laakso M, Siitonen O, Niskanen L, Rönnemaa T (1987) Macrovascular complications in relation to hyperinsulinaemia in non-insulin-dependent diabetes mellitus. Diab Metab 13: 345–349Google Scholar
  28. 28.
    Uusitupa M, Siitonen O, Pyörälä K, Mustonen J, Voutilainen E, Hersio K, Pentila I (1987) Relationship of blood pressure and left ventricular mass to serum insulin levels in newly diagnosed non-insulin-dependent (Type 2) diabetic patients and in non-diabetic subjects. Diabetes Res 4: 19–25Google Scholar
  29. 29.
    Jensen T, Borch Johnsen K, Kofoed-Enevoldsen A, Deckert T (1987) Coronary heart disease in young Type 1 (insulin-dependent) diabetic patients with and without diabetic nephropathy: incidence and risk factors. Diabetologia 30: 144–148Google Scholar
  30. 30.
    Haffner SM (1987) Hyperinsulinaemia as a possible etiology for the high prevalence of non insulin dependent diabetes in Mexican Americans. Diab Metab 13: 337–344Google Scholar
  31. 31.
    Aronoff SL, Bennett PH, Gordon P, Rushforth N, Miller M (1977) Unexplained hyperinsulinaemia in normal and “prediabetic” Pima Indians compared with normal Caucasians. An example of racial differences in insulin secretion. Diabetes 26: 827–840Google Scholar
  32. 32.
    Frohman LA, Doeblin TD, Emerling FG (1969) Diabetes in the Seneca Indians. Plasma insulin responses to oral carbohydrate. Diabetes 18: 38–43Google Scholar
  33. 33.
    Sicree RA, Zimmet P, King HOM, Coventry JS (1987) Plasma insulin response among Nauruans: prediction of deterioration in glucose tolerance over 6 yr. Diabetes 36: 179–186Google Scholar
  34. 34.
    Ingelfinger JA, Bennett PH, Liebow IM, Miller M (1976) Coronary heart disease in the Pima Indians: electrocardiographic findings and post mortem evidence of myocardial infarction in a population with a high prevalence of diabetes mellitus. Diabetes 25: 561–565Google Scholar
  35. 35.
    Pettitt DJ, Lisse JR, Knowler WC, Bennett PH (1982) Mortality as a function of obesity and diabetes mellitus. Am J Epidemiol 115: 359–366Google Scholar
  36. 36.
    Young IR, Stout RW (1987) Effects of insulin and glucose on the cells of the arterial wall: interaction of insulin with dibutyryl cyclic AMP and low density lipoprotein in arterial cells. Diab Metab 13: 301–306Google Scholar
  37. 37.
    Wiseman M, Viberti G, Mackintosh D, Jarrett RJ, Keen H (1984) Glycaemia, arterial pressure and microalbuminuria in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 26: 401–405Google Scholar
  38. 38.
    Björntorp P (1987) Adipose tissue distribution, plasma insulin, and cardiovascular disease. Diab Metab 13: 381–385Google Scholar
  39. 39.
    Florey C du V, Uppal S, Lowy C (1976) Relation between blood pressure, weight, and plasma sugar and serum insulin levels in school children aged 9–12 years in Westland, Holland. Br Med J 1: 1368–1371Google Scholar
  40. 40.
    Uusitupa M, Siitonen O, Voutilainen E, Aro A, Hersio K, Pyörälä K, Penttila I, Ehnholm C (1986) Serum lipids and lipoproteins in newly diagnosed non-insulin-dependent (Type II) diabetic patients, with special reference to factors influencing HDL-cholesterol and triglyceride levels. Diabetes Care 9: 17–22Google Scholar
  41. 41.
    Lichenstein MJ, Yarnell JWG, Elwood PC, Beswick AD, Sweetnam PM, Marks V, Teale D, Riad-Fahmy D (1987) Sex hormones, insulin, lipids, and prevalent ischemic heart disease. Am J Epidemiol 126: 647–657Google Scholar
  42. 42.
    Björntorp P, de Jounge K, Sjöstrom L, Sullivan L (1970) The effect of physical training on insulin production in obesity. Metabolism 19: 631–638Google Scholar
  43. 43.
    Thomas BJ, Jarrett RJ, Keen H, Ruskin HJ (1982) Relation of habitual diet to fasting plasma insulin concentration and the insulin response to oral glucose. Hum Nutr Clin Nutr 36C: 49–56Google Scholar
  44. 44.
    Modan M, Halkin H, Fuchs Z, Lusky A, Chetrit A, Segal P, Eshkol A, Almog S, Shefi M (1987) Hyperinsulinaemia — a link between glucose intolerance, obesity, hypertension, dyslipoproteinemia, elevated serum uric acid and internal cation imbalance. Diab Metab 13: 375–380Google Scholar
  45. 45.
    Faber OK, Christensen K, Kehlet H, Madsbad S, Binder C (1981) Decreased insulin removal contributes to hyperinsulinaemia in obesity. J Clin Endocrinol 53: 618–621Google Scholar
  46. 46.
    Bonora E, Coscelli C, Butturini U (1986) Insulin metabolism is a major factor responsible for high or low peripheral insulin levels in response to oral glucose loading in the healthy man. Ann Nutr Metab 30: 219–226Google Scholar
  47. 47.
    Barrett-Connor E (1985) Obesity, atherosclerosis, and coronary artery disease. Ann Int Med 106: 1010–1019Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • R. J. Jarrett
    • 1
  1. 1.Division of Community MedicineUnited Medical and Dental Schools of Guy's and St. Thomas's HospitalsLondonUK

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