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The contrast-enhanced CT scan and the radionuclide brain scan: Parallel mechanisms of action in the detection of supratentorial astrocytomas


The preoperative contrast-enhanced CT scan and the radionuclide brain scan of 70 patients with surgically verified supratentorial astrocytomas were evaluated and compared. The results indicate parallel mechanisms of action of contrast enhancement and radionuclide uptake. These diagnostic modalities apparently mirror the integrity of the blood-brain barrier (BBB) and therefore are useful in assessing the degree of malignancy of supratentorial gliomas. However, lesions with an intact BBB will be missed with RN imaging. These lesions and/or the associated mass effect will be detected with contrast-enhanced computed tomography. Our findings firmly establish contrast-enhanced CT as the primary investigative tool in the suspected brain tumor.

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  1. 1.

    Ambrose, J.: Computerized X-ray scanning of the brain. J. Neurosurg. 40, 679–695 (1974)

  2. 2.

    Bakay, L.: Basic aspects of brain tumor localization by radioactive substances. A review of current concepts. J. Neurosurg. 27, 239–245 (1967)

  3. 3.

    Butler, A. R., Horii, S. C., Kricheff, I. I., et al.: Contrast enhancement in astrocytomas: A statistical analysis of the parameters of malignancy and the positive contrast enhancement CT scan. Presented at the Sixty-Third Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, Ill., 1977

  4. 4.

    Crocker, E. F., Zimmerman, R. A., Phelps, M. E., Kuhl, D. E.: The effect of steroids on the extravascular distribution of radiographic contrast material and technetium pertechnetate in brain tumors as determined by computed tomography. Radiology 119, 471–474 (1976)

  5. 5.

    Ethier, R., Sherwin, A., Taylor, S.: Computerized angiotomography. The use of 100 cc. Hypaque-M60%. Clinical and experimental results. Presented at the First International Symposium on Computerized Axial Tomography, Montreal 1974

  6. 6.

    Gado, M. H., Phelps, M. E., Coleman, R. E.: An extravascular component of contrast enhancement in cranial computed tomography. Parts I and II. Radiology 117, 589–597 (1975)

  7. 7.

    Hatam, A., Bergvall, R., Lewander, S., et al.: Contrast medium enhancement with time in computer tomography differential diagnosis of intracranial lesions. Acta Radiol. [Diagn.] (Stockh.) 346, 63–81 (1975)

  8. 8.

    Holman, B. L.: The blood brain barrier: Anatomy and physiology. Prog. Nucl. Med. 1, 236–248 (1972)

  9. 9.

    Long, D. M.: Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J. Neurosurg. 32, 127–144 (1970)

  10. 10.

    Long, D. M.: Capillary ultrastructure and the blood brain barrier. Human brain tumors. 6th Int. Congr. of Neuropathology, Paris, pp. 995–996 1970

  11. 11.

    Moreno, J. B., Deland, F. H.: Brain scanning in the diagnosis of astrocytomas of the brain. J. Nucl. Med. 12, 107–111 (1971)

  12. 12.

    New, P. F. J., Scott, W. R., Schnur, J. A., et al.: Computerized axial tomography with the EMI scanner. Radiology 110, 109–123 (1974)

  13. 13.

    Penning, L., Front, D., Bechar, K., et al.: Factors governing the uptake of pertechnetate by human brain tumors. A scintigraphic study. Brain 96, 225–234 (1973)

  14. 14.

    Shuttleworth, E. C.: Barrier phenomena in brain tumors. Prog. Exp. Tumor Res. 17, 279–290 (1972)

  15. 15.

    Witcofski, R. L., Maynard, C. D., Roper, T. J.: A comparative analysis of the accuracy of the technetium-99m pertechnetate brain scan. Follow-up of 1000 patients. J. Nucl. Med. 8, 187–196 (1967)

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Butler, A.R., Passalaqua, A.M., Berenstein, A. et al. The contrast-enhanced CT scan and the radionuclide brain scan: Parallel mechanisms of action in the detection of supratentorial astrocytomas. Neuroradiology 16, 491–494 (1978).

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  • Public Health
  • Compute Tomography
  • Radionuclide
  • Brain Tumor
  • Astrocytoma