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Metrizamide washout as a measure of CSF bulk flow


Metrizamide was injected into the ventricular system of three adults and five children with indwelling ventricular catheters and subcutaneous CSF reservoirs. A first-order rate constant, k, for metrizamide washout from one lateral ventricle was determined with reference to ventricular metrizamide concentration on serial (up to six) postinjection CT scans. Lateral ventricular volume, V v, was estimated after metrizamide injection by a planimetric method and by partial volume analysis, an interactive computerized technique. The rate of lateral ventricular CSF formation, I f, was calculated as kxV v and ranged from 0.0622 to 0.103 ml/min. precise measurements of lateral ventricular CSF bulk flow depend upon adquate mixing of the injected contrast material with ventricular CSF and accurate measurements of lateral ventricular volume.

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Rottenberg, D.A., Deck, M.D.F. & Allen, J.C. Metrizamide washout as a measure of CSF bulk flow. Neuroradiology 16, 203–206 (1978). https://doi.org/10.1007/BF00395250

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  • Catheter
  • Contrast Material
  • Washout
  • Lateral Ventricle
  • Precise Measurement