Metrizamide was injected into the ventricular system of three adults and five children with indwelling ventricular catheters and subcutaneous CSF reservoirs. A first-order rate constant, k, for metrizamide washout from one lateral ventricle was determined with reference to ventricular metrizamide concentration on serial (up to six) postinjection CT scans. Lateral ventricular volume, V v, was estimated after metrizamide injection by a planimetric method and by partial volume analysis, an interactive computerized technique. The rate of lateral ventricular CSF formation, I f, was calculated as kxV v and ranged from 0.0622 to 0.103 ml/min. precise measurements of lateral ventricular CSF bulk flow depend upon adquate mixing of the injected contrast material with ventricular CSF and accurate measurements of lateral ventricular volume.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Deck, M. D. F., Potts, D. G.: Movements of ventricular fluid levels due to cerebrospinal fluid formation. Am. J. Roentgenol. 106, 354–368 (1969)
Drayer, B. P., Rosenbaum, A. E., Higman, H. B.: Cerebrospinal fluid imaging using serial metrizamide CT cisternography. Neuroradiology 13, 7–17 (1977)
Pentlow, K. S., Rottenberg, D. A., Deck, M. D. F.: Partial volume summation: a simple approach to ventricular volume determination from computed tomography. These proceedings, pp. 130–132
Portnoy, H. D., Schulte, R. R., Fox, J. L., et al.: Anti-siphon and reversible occlusion valves for shunting in hydrocephalus and preventing post-shunt subdural hematomas. J. Neurosurg. 38, 729–738 (1973)
Rottenberg, D. A., Howieson, J., Deck, M.D.F.: The rate of CSF formation in man: preliminary observations on metrizamide washout as a measure of CSF bulk flow. Ann. Neurol. 2, 503–510 (1977)
Rottenberg, D. A., Pentlow, K. S., Deck, M. D. F., Allen, J. C.: Determination of ventricular volume following metrizamide CT ventriculography. These proceedings, pp. 136–139
About this article
Cite this article
Rottenberg, D.A., Deck, M.D.F. & Allen, J.C. Metrizamide washout as a measure of CSF bulk flow. Neuroradiology 16, 203–206 (1978). https://doi.org/10.1007/BF00395250
- Contrast Material
- Lateral Ventricle
- Precise Measurement