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Reexamination of histological findings of ileal sarcomas induced in rats given diet containing bracken fern

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The ileal sarcomas induced in rats given diet containing bracken fern were examined microscopically and electron microscopically. These ileal sarcomas, which were induced at high incidence (80%-44%), have previously been identified as spindle cell fibrosarcomas. However, studies showed that they should be diagnosed as malignant fibrous histiocytomas (MFH) being classified into the following four histological types; fibrous, pleomorphic, giant cell and myxoid type. No types of sarcomas other than MFH were found in the ileum.

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  1. Enjoji M, Hashimoto H, Tsuneyoshi M, Iwasaki H (1980) Malignant fibrous histiocytoma. A clinicopathologic study of 130 cases. Acta Pathol Jpn 30:727–741

  2. Fu YS, Gabbiani G, Kaye GI, Lattes R (1975) Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies. Cancer 35:176–198

  3. Hirono I, Shibuya C, Fushimi K, Haga M (1970) Studies on carcinogenic properties of bracken, Pteridium aquilinum. J Natl Cancer Inst 45:179–188

  4. Hirono I, Shibuya C, Shimizu M, Fushimi K (1972) Carcinogenic activity of processed bracken used as human food. J Natl Cancer Inst 48:1245–1250

  5. Hirono I, Hosaka S, Kuhara K (1982) Enhancement by bracken of induction of tumours of the upper alimentary tract by N-propyl-N-nitrosourethan. Br J Cancer 46:423–427

  6. Inoue A, Aozasa K, Tsujimoto M, Tamai M, Chatani F, Ueno H (1984) Immunohistological study on malignant fibrous histiocytoma. Acta Pathol Jpn 34:759–765

  7. Iwasaki H, Enjoji M (1979) Infantile and adult fibrosarcomas of the soft tissues. Acta Pathol Jpn 29:377–388

  8. Kato T (1978) Experimental studies on carcinogenicity of bracken, Pteridium aquilinum. Acta Sch Med Univ Gifu 26:265–276

  9. Kauffman SL, Stout AP (1961) Histiocytic tumors (fibrous xanthoma and histiocytoma) in children. Cancer 14:469–482

  10. Kempson RL, Kyriakos M (1972) Fibroxanthosarcoma of the soft tissues — A type of malignant fibrous histiocytoma. Cancer 29:961–976

  11. Konishi Y, Maruyama H, Mii Y, Miyauchi Y, Yokose Y, Masuhara K (1982) Malignant fibrous histiocytomas induced by 4-(hydroxyamino) quinoline 1-oxide in rats. J Natl Cancer Inst 68: 859–865

  12. Lagace R, Delage C, Seemayer TA (1979) Myxoid variant of malignant fibrous histiocytoma. Ultrastructural observations. Cancer 43:526–534

  13. Maekawa A, Ogiu T, Onoda H, Furuta K, Matsuoka C, Ohno Y, Tanigawa H, Salmo GS, Matsuyama M, Hayashi Y (1984) Malignant fibrous histiocytomas induced in rats by polymers. J Cancer Res Clin Oncol 108:364–365

  14. Miller R, Kreutner A, Kurtz SM (1980) Malignant inflammatory histiocytoma (inflammatory fibrous histiocytoma). Report of a patient with four lesions. Cancer 45:179–187

  15. O'Brien JE, Stout AP (1964) Malignant fibrous xanthomas. Cancer 17:1445–1455

  16. Ozzello L, Stout AP, Murray MR (1963) Cultural characteristics of malignant histiocytomas and fibrous xanthomas. Cancer 16:331–344

  17. Pradhan SN, Chung EB, Ghosh B, Paul BD, Kapadia GJ (1974) Potential carcinogens. I. Carcinogenicity of some plant extracts and their tannin-containing fractions in rats. J Natl Cancer Inst 52:1579–1582

  18. Pritchard DJ, Soule EH, Taylor WF, Ivins JC (1974) Fibrosarcoma —A clinicopathologic and statistical study of 199 tumors of the soft tissues of the extremities and trunk. Cancer 33:888–897

  19. Stout AP (1948) Fibrosarcoma. The malignant tumor of fibroblasts. Cancer 1:30–63

  20. Weiss SW, Enzinger FM (1978) Malignant fibrous histiocytoma. An analysis of 200 cases. Cancer 41:2250–2266

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Correspondence to H. Ogino.

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Ogino, H., Fujimoto, M. & Hirono, I. Reexamination of histological findings of ileal sarcomas induced in rats given diet containing bracken fern. J Cancer Res Clin Oncol 112, 6–10 (1986). https://doi.org/10.1007/BF00394931

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Key words

  • Ileal sarcoma
  • Malignant fibrous histiocytoma
  • Bracken carcinogenicity