The ileal sarcomas induced in rats given diet containing bracken fern were examined microscopically and electron microscopically. These ileal sarcomas, which were induced at high incidence (80%-44%), have previously been identified as spindle cell fibrosarcomas. However, studies showed that they should be diagnosed as malignant fibrous histiocytomas (MFH) being classified into the following four histological types; fibrous, pleomorphic, giant cell and myxoid type. No types of sarcomas other than MFH were found in the ileum.
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Ogino, H., Fujimoto, M. & Hirono, I. Reexamination of histological findings of ileal sarcomas induced in rats given diet containing bracken fern. J Cancer Res Clin Oncol 112, 6–10 (1986). https://doi.org/10.1007/BF00394931
- Ileal sarcoma
- Malignant fibrous histiocytoma
- Bracken carcinogenicity