Human Genetics

, Volume 37, Issue 3, pp 279–284 | Cite as

Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase

  • N. C. Sun
  • C. R. Y. Sun
  • E. H. Y. Chu
Original Investigations
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Summary

In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium.

Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-1-phosphate uridyltransferase to the centromeric region of this chromosome (2q11-2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1.

Keywords

Internal Medicine Metabolic Disease Somatic Cell Acid Phosphatase Human Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • N. C. Sun
    • 1
  • C. R. Y. Sun
    • 1
  • E. H. Y. Chu
    • 2
  1. 1.Biology DivisionOak Ridge National LaboratoryOak RidgeUSA
  2. 2.Department of Human GeneticsUniversity of Michigan, Medical SchoolAnn ArborUSA

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