Journal of Cancer Research and Clinical Oncology

, Volume 115, Issue 5, pp 474–475 | Cite as

Serological screening for a mucine-like carcinoma-associated antigen (MCA) in patients with gastrointestinal tract malignancies

  • Werner Scheithauer
  • Daniela Mairinger
Rapid Communication


Mouse monoclonal antibody b-12 identifies a high-molecular-mass glycoprotein antigen strongly expressed by breast carcinoma cells. Since immunohistochemical studies have also demonstrated some reacitivity with other epithelial neoplasms, and since “mucine-like carcinoma-associated antigen” (MCA) has gained considerable interest as a tumor marker in breast cancer, we have investigated 34 patients with histologically proven advanced gastrointestinal malignancies for the presence of elevated MCA serum levels. Our data suggest that screening for and/or monitoring of MCA in these tumors is un-likely to have any practical clinical relevance. The possible role of MCA as a marker in tissue specimens for abortive adenomatous differentiation in gastrointestinal (and other) neoplasms, however, remains to be determined.

Key words

MCA Tumor marker Gastrointestinal tumors 



mucine-like carcinoma-associated antigen


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Werner Scheithauer
    • 1
  • Daniela Mairinger
    • 1
  1. 1.Department of Gastroenterology and Hepatology IIVienna University School of MedicineViennaAustria

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