Journal of Cancer Research and Clinical Oncology

, Volume 115, Issue 5, pp 474–475 | Cite as

Serological screening for a mucine-like carcinoma-associated antigen (MCA) in patients with gastrointestinal tract malignancies

  • Werner Scheithauer
  • Daniela Mairinger
Rapid Communication
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Summary

Mouse monoclonal antibody b-12 identifies a high-molecular-mass glycoprotein antigen strongly expressed by breast carcinoma cells. Since immunohistochemical studies have also demonstrated some reacitivity with other epithelial neoplasms, and since “mucine-like carcinoma-associated antigen” (MCA) has gained considerable interest as a tumor marker in breast cancer, we have investigated 34 patients with histologically proven advanced gastrointestinal malignancies for the presence of elevated MCA serum levels. Our data suggest that screening for and/or monitoring of MCA in these tumors is un-likely to have any practical clinical relevance. The possible role of MCA as a marker in tissue specimens for abortive adenomatous differentiation in gastrointestinal (and other) neoplasms, however, remains to be determined.

Key words

MCA Tumor marker Gastrointestinal tumors 

Abbreviations

MCA

mucine-like carcinoma-associated antigen

References

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  2. Staehli C, Takacs B, Miggiano V, Staehlin T, Carman H (1985) Monoclonal antibodies against antigens on breast cancer cells. Experientia 41: 1377–1381Google Scholar
  3. Staehli C, Caravatti M, Aeschbacher M, Kocyba C, Takacs B, Carmann H (1988) Mucine-like carcinoma-associated antigen defined by three monoclonal antibodies against different epitopes. Cancer Res 48: 6799–6802Google Scholar
  4. Zenklusen HR, Overbeck J, Staehli C, Gudat F, Rolink J, Heitz PU (1988) The immunohistochemical reactivity of a new anti-epithelial monoclonal antibody (MAb b-12) against breast carcinoma and other normal and neoplastic human tissues. Virchows Arch [A] 413:3–10Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Werner Scheithauer
    • 1
  • Daniela Mairinger
    • 1
  1. 1.Department of Gastroenterology and Hepatology IIVienna University School of MedicineViennaAustria

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