Current Genetics

, Volume 5, Issue 3, pp 221–225

Nucleotide sequence of the cytochrome B gene and adjacent regions from rat liver mitochondrial DNA

  • Gabriele Görtz
  • Horst Feldmann


The nucleotide sequence of a 1.76 Kbp segment from rat liver mitochondrial DNA has been determined. It contains the gene for the cytochrome b apoprotein and the tRNA genes for threonine, glutamic acid, and proline. The arrangement of these genes in rat liver mitochondria is the same as in human (Anderson et al. 1981) or mouse (Bibb et al. 1981) mitochondria. The comparison of the cytochrome b sequences so far determined, reveals that several regions in these proteins are highly conserved.

Key words

Mammalian mitochondria Rat liver Cytochrome b gene DNA sequencing 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson S, Bankier AT, Barrell BG, de Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DC, Roe BA, Sanger F, Schreier PH, Smith AJH, Staden R, Young IG (1981) Nature 290:457–464Google Scholar
  2. Anderson S, De Bruijn MLH, Coulson AR, Eperon IC, Sanger F, Young IG (1982) J Mol Biol 156:683–717Google Scholar
  3. Bibb MJ, van Etten RA, Wright CT, Walberg MW, Clayton DA (1981) Cell 26:167–180Google Scholar
  4. Birnboim HC, Doly J (1979) Nucleic Acids Res 7:1513–1523Google Scholar
  5. Bolivar F, Rodriguez RL, Greene PJ, Betlach MC, Heynecker HL, Boyer HW, Crosa JH, Falkow S (1977) Gene 2:95–113Google Scholar
  6. Brown WM, Wilson AC (1979) Proc Natl Acad Sci USA 76:1967–1971Google Scholar
  7. Buzzo K, Fouts DL, Wolstenholme DR (1978) Proc Natl Acad Sci USA 75:909–913Google Scholar
  8. Feldmann H, Grosskopf R (1979) Curr Genet 1:13–19Google Scholar
  9. Grosskopf R, Feldmann H (1981a) Curr Genet 4:151–158Google Scholar
  10. Grosskopf R, Feldmann H (1981b) Curr Genet 4:191–196Google Scholar
  11. Kobayashi M, Yaginuma K, Seki T, Koike K (1980) In: Kroon AM, Saccone C (eds) The Organization and Expression of the Mitochondrial Genome. Elsevier/North Holland, Amsterdam, pp 221–229Google Scholar
  12. Kobayashi M, Seki T, Yaginuma K, Koike K (1981) Gene 16:297–307Google Scholar
  13. Lederberg EM, Cohen SN (1974) J Bacteriol 119:1072–1074Google Scholar
  14. Montoya J, Ojala D, Attardi G (1981) Nature 290:465–470Google Scholar
  15. Nobrega FG, Tzagoloff A (1980) J Biol Chemistry 225:9828–9837Google Scholar
  16. Pech M, Streeck RE, Zachau HG (1979) Cell 18:883–893Google Scholar
  17. Saccone C, Cantatore P, Gadaleta G, Gallerani R, Lanave C, Pepe G, Kroon AM (1981) Nucleic Acids Res 9:4139–4148Google Scholar
  18. Sekiya T, Kobayashi M, Seki T, Koike K (1980) Gene 11:53–62Google Scholar
  19. Upholt WB, Dawid IB (1979) Cell 11:571–583Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Gabriele Görtz
    • 1
  • Horst Feldmann
    • 1
  1. 1.Institut für Physiologische Chemie, Physikalische Biochemie und ZellbiologieUniversität MünchenMünchen 2Germany

Personalised recommendations