Journal of Cancer Research and Clinical Oncology

, Volume 114, Issue 1, pp 108–109 | Cite as

Role of recombinant interferon alpha2 and cimetidine in patients with advanced malignant melanoma

  • Tariq I. Mughal
  • William A. Robinson
  • M. Roy Thomas
  • Robert Spiegel
Original Papers Clinical Oncology or Epidemiology


Following recent reports suggesting that the addition of eimetidine to interferon may enhance response rates in patients with metastatic malignant melanoma, we have completed a Phase II study of the use of recombinant alpha2 interferon and cimetidine in patients with advanced malignant melanoma and who had progressive disease following interferon therapy alone. We observed two partial responses, no complete responses, and two patients had stable disease. Toxicity encountered was analogous to that of interferon alone. We conclude that the additional of cimetidine to alpha interferon is not beneficial in the treatment of advanced metastatic malignant melanoma.

Key words

Interferon Cimetidine Melanoma 


  1. Armitage JO, Sidner RD (1979) Antitumour effect of cimetidine? Lancet I:882–883CrossRefGoogle Scholar
  2. Borgstrum S, Von Eyben FE, Flodgren P (1983) Human leukocyte interferon and cimetidine for metastatic melanoma. N Engl J Med 307:1080–1081Google Scholar
  3. Gutterman JU, Fine S, Quesada et al. (1982) Recombinant leukocyte A interferon: pharmacokinetics, single-dose tolerance, and biologic effects in cancer patients. Ann Intern Med 96:549–556PubMedGoogle Scholar
  4. Hengst JC, Kempf RA, Kan-Mitchell J et al. (1983) Immunological effects of recombinant interferon-alpha2 in cancer patients. J Biol Resp Modif 2:516–527Google Scholar
  5. Horning SJ, Levine JF, Miller RA et al. (1982) Clinical and immunologic effects of recombinant leukocyte A interferon in eight patients with advanced cancer. JAMA 247:1718–1722PubMedGoogle Scholar
  6. Isaacs A, Lindemann JJ (1957) Virus interference: the interferon. Proc Roy Soc Lond (Biol) 147:258–267Google Scholar
  7. Kirkwood JM, Ernstoff MS (1984) Interferons in the treatment of human cancer. J Clin Oncol 2:336–352PubMedGoogle Scholar
  8. Miller AB, Hoogstraten B, Staquet M et al. (1981) Reporting results of cancer treatment. Cancer 47:207–214PubMedGoogle Scholar
  9. Osband ME, Hamilton D, Shen Y-J et al. (1981) Successful tumour immunotherapy with cimetidine in mice. Lancet I:636–638CrossRefGoogle Scholar
  10. Robinson WA, Mughal TI, Thomas MR, Johnson M, Spiegel R (1986) Treatment of metastatic malignant melanoma with recombinant interferon alpha 2. Immunobiology 172:275–282PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Tariq I. Mughal
    • 1
  • William A. Robinson
    • 1
  • M. Roy Thomas
    • 1
  • Robert Spiegel
    • 2
  1. 1.Melanoma Clinic Research Center University of Colorado Health Sciences CenterDenverUSA
  2. 2.Schering CorporationKenilworthUSA

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