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Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis

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Summary

We have studied the effects of disulfiram (DSF) administration on the metabolism of nitrosodiethylamine (NDEA) in rats during acute and chronic administration. DSF was found to have the following effects during the course of carcinogenesis: (a) marked decrease in the exhalation of 14CO2 derived from 14C-NDEA; (b) reduction of the total levels of DNA and RNA ethylation in the liver. In acute experiments DSF caused an incrase in the amount of NDEA in organs and in the urine. We suggest that inhibition of NDEA biotransformation and the subsequent decrease in the total level of DNA ethylation may prevent specific chemical interactions relevant to carcinogenesis.

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Abbreviations

DSF:

disulfiram

NDEA:

N-nitrosodiethylamine

References

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Correspondence to N. Frank.

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Hadjiolov, D., Frank, N., Mundt, D. et al. Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis. J Cancer Res Clin Oncol 108, 281–285 (1984). https://doi.org/10.1007/BF00390458

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Key words

  • Disulfiram
  • Nitrosodiethylamine
  • Carcinogenesis
  • DNA
  • RNA
  • Alkylation
  • Metabolism