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Translocation D/D involving two homologous chromosomes of the pair 15

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Summary

A translocation between two homologues of chromosomes 15 was identified in a phenotypically normal female with the R-banding technique. The C-banding technique demonstrated an abnormally large band on the translocation chromosome. This finding suggests a possibility that the translocation might be due to breaks in the short arms or to fusion at telomeric ends. The patient had four spontaneous abortions and no normal pregnancy.

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References

  1. Hawkey, C. J., Smithies, A.: The Prader-Willi syndrome with a 15/15 translocation. J. med. Genet. 13, 152–157 (1976)

  2. Hsu, T. C., Pathak, S., Chen, T. R.: The possibility of latent centromere and a proposed nomenclature system for total chromosome and whole arm translocations. Cytogenet. Cell Genet. 15, 41–49 (1975)

  3. Lucas, M.: Translocation between both members of chromosome pair number 15 causing recurrent abortions. Ann. Hum. Genet. Lond. 32, 347–352 (1969)

  4. Yoshida, M. C., Nomoto, N., Sasaki, M.: Quinacrine fluorescence patterns in somatic chromosomes of a t (15q15q) carrier. Humangenetik 15, 66–70 (1972)

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Žižka, J., Balíĉek, P. & Finková, A. Translocation D/D involving two homologous chromosomes of the pair 15. Hum Genet 36, 123–125 (1977). https://doi.org/10.1007/BF00390444

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Keywords

  • Internal Medicine
  • Metabolic Disease
  • Spontaneous Abortion
  • Homologous Chromosome
  • Normal Pregnancy