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Chromosomal banding patterns in human large bowel adenomas


Chromosome studies were performed on direct preparations of 38 benign human large bowel adenomas by fluorescent banding techniques. Five adenomas had a normal diploid karyotype line. Six adenomas had numerical abnormalities, and seven polypoid lesions exhibited structural and numerical changes. In 20 adenomas without analyzable metaphases, it was presumed that the cells were dividing at a lower rate. Mosaics were observed in 25% of cases. The most common finding was trisomy of 7, 8, or 13.

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  1. Astler VA, Coller FA (1954) The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 139:846–855

  2. Atkin NB (1976) Tumours of the alimentary tract. In: Wolsky A (ed) Cytogenetic aspects of malignant transformation: Experimental biology and medicine, vol 6. Karger, Basel, pp 85–91

  3. Baker MC, Atkin NB (1970) Chromosome abnormalities in polyps and carcinomas of the large bowel. Proc R Soc Med 63 (suppl): 9–10

  4. Enterline HT, Arvan DA (1967) Chromosome constitution of adenoma and adenocarcinoma of the colon. Cancer 20:1746–1759

  5. ISCN (1978) An international system for human cytogenetic nomenclature. Cytogenet Cell Genet 21:309–404

  6. Lipkin M, Deschner E, Troncale F (1970) Cell differentiation and the development of colonic neoplasms. Gastroenterology 59:303–307

  7. Lubs HA, Clark R (1963) The chromosome complement of human solid tumors. I. Gastrointestinal tumors and technique. N Engl J Med 268:907–911

  8. Lubs HA, Kotler S (1967) The prognostic significance of chromosome abnormalities in colon tumors. Ann Intern Med 67:328–336

  9. Mark J, Mitelman F, Dencker H, Norryd C, Tranberg KG (1973) The specificity of the chromosomal abnormalities in human colonic polyps. Acta Pathol Microbiol Scand [A] 81:85–90

  10. Miles CP (1967) Chromosome analysis of solid tumors. II. Twenty-six epithelial tumors. Cancer 20:1274–1287

  11. Mitelman G, Mark J, Nilsson PG, Dencker H, Norryd C, Tranberg KG (1974) Chromosome banding pattern in human colonic polyps. Hereditas 78:63–68

  12. Reichmann A, Ridell RH, Martin P, Levin B (1980) Double minutes in human large bowel cancer. Gastroenterology 79:334–339

  13. Reichmann A, Martin P, Levin B (1981) Chromosomal banding pattern in human large bowel cancer. Int J Cancer 28:431–440

  14. Reichmann A, Martin P, Levin B (1982a) Karyotypic findings in a colonic villous adenoma. Cancer Genet Cytogenet 7:51–57

  15. Reichmann A, Levin B, Martin P (1982b) Human large-bowel cancer: Correlation of clinical and histopathological features with banded chromosomes. Int J Cancer 29:625–629

  16. Reichmann A, Martin P, Levin B (1983) Chromosomes in human large bowel adenomas: Significance of karyotypic changes (Abstract). Gastroenterology 84:1283

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Correspondence to Amelia Reichmann.

Additional information

Data in this paper were reported in part at the Annual Meeting of the American Gastroenterological Association on May 1983. Washington, D.C. (A. Reichmann, P. Martin, and B. Levin 1983).

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Reichmann, A., Martin, P. & Levin, B. Chromosomal banding patterns in human large bowel adenomas. Hum Genet 70, 28–31 (1985).

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  • Adenoma
  • Metabolic Disease
  • Banding Pattern
  • Common Finding
  • Chromosomal Banding