Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy
- 765 Downloads
The effect of maternal age on the incidence of chromosomally normal spontaneous abortion and different categories of chromosome abnormality among all clinically recognized human pregnancies was evaluated. The results provide no evidence for a significant association of age with sex chromosome monosomy or polyploidy, but clearly demonstrate an effect of age on the frequency of trisomy and chromosomally normal spontaneous abortions. Estimated maternal age-specific rates of trisomy among all recognized pregnancies were calculated and suggest that a majority of oocytes of women aged 40 years and older may be aneuploid.
KeywordsInternal Medicine Metabolic Disease Special Reference Chromosome Abnormality Spontaneous Abortion
Unable to display preview. Download preview PDF.
- Ferguson-Smith MA (1979) Group report: Maternal age-specific incidence of chromosome aberrations at amniocentesis. In: Murken J-D, Stengel-Rutkowski S, Schwinger E (eds) Prenatal diagnosis. Enke, Stuttgart, pp 1–14Google Scholar
- Hassold T, Warburton D, Kline J, Stein Z (to be published) The relationship of maternal age and trisomy among trisomic spontaneous abortions. Am J Hum GenetGoogle Scholar
- Hook EB (1981a) Down syndrome: Its frequency in human populations and some factors pertinent to variation in rates. In: de la Cruz F, Gerald P (eds) Trisomy 21 (Down syndrome) — Research perspectives. University Park Press, Baltimore, pp 3–67Google Scholar
- Jacobs P (1975) The load due to chromosome abnormalities in man. In: Salzano FM (ed) The role of natural selection in human evolution. North Holland Publishing Company, Amsterdam, pp 337–353Google Scholar
- Lauritsen J (1976) Aetiology of spontaneous abortion: A cytogenetic and epidemiological study of 288 abortuses and their parents. Acta Obstet Gynecol Scand [Suppl] 52:1–29Google Scholar
- Miller JF, Williamson E, Glue J, Gordon YB, Grudzinskas JG, Sykes A (1980) Fetal loss after implantation. Lancet II:626–630Google Scholar
- Stein Z, Kline J, Susser E, Shrout P, Warburton D, Susser M (1980) Maternal age and spontaneous abortion. In: Porter IH, Hook EB (eds) Human embryonic and fetal death. Academic Press, New York, pp 107–127Google Scholar