Archives of Orthopaedic and Trauma Surgery

, Volume 116, Issue 8, pp 510–513 | Cite as

Gorham massive osteolysis

  • K. Sato
  • S. Yamamura
  • H. Sugiura
  • T. Mieno
  • T. Nagasaka
  • N. Nakashima
Current Problem Case


Gorham syndrome (massive osteolysis) is a very rare tumour-like lesion characterized by progressive osteolysis. The diagnosis must be confirmed by the microscopic finding of intramedullary angioma-like vascular structures. We report a case of a 15-year-old boy with a pathological fracture in his left humerus. Imaging modalities such as magnetic resonance imaging, computed tomography, angiography and bone scintigraphy failed to disclose to tumorous lesion that filled a cavity in the left humerus. After observing the boy's progress for 6 months, a temporary diagnosis of Gorham syndrome was made, and surgical treatment was chosen. After resection of the left humeral head and the proximal one-quarter of the humerus, thorough curettage was performed in the distal humerus and an intramedullary artificial humeral head fixed with adequate success. Pathological examination of the specimen revealed intramedullary haemangioma of the humerus.


Public Health Compute Tomography Magnetic Resonance Imaging Image Modality Pathological Examination 
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  1. 1.
    Beck V, Haicl Z, Kolar J, Bednar B (1981) Radiotherapy in massive angiomatous osteolysis (Gorham-Stout's syndrome). Strahlentherapie 157:813–818PubMedGoogle Scholar
  2. 2.
    Cannon SR (1986) Massive osteolysis: a review of seven cases. J Bone Joint Surg [Br] 68:24–28Google Scholar
  3. 3.
    Choma ND, Biscotti CV, Bauer TW, Mehta AC, Licata AA (1987) Gorham's disease: a case report and review of the literature. Am J Med 83:1151–1156CrossRefPubMedGoogle Scholar
  4. 4.
    Gorham LW, Stout AP (1955) Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone). J Bone Joint Surg [Am] 37:985–1004Google Scholar
  5. 5.
    Gorham LW, Wright AW, Schultz HH, Maxon FJ (1954) Disappearing bones: a rare form of massive osteolysis, report of two cases, one with autopsy findings. Am J Med 17:674–682CrossRefPubMedGoogle Scholar
  6. 6.
    Halliday DR, Pugh DG, Young HH (1964) Massive osteolysis and angiomatosis. Radiology 82:637–644PubMedGoogle Scholar
  7. 7.
    Hambach R, Pujman J, Maly V (1958) Massive osteolysis due to hemangiomatosis: report of case of Gorham's disease with autopsy. Radiology 71:43–47PubMedGoogle Scholar
  8. 8.
    Hejgaard N, Olsen PR (1987) Massive Gorham osteolysis of the right hemipelvis complicated by chylothrax: report of a case in a 9-year-old boy successfully treated by pleurodesis. J Pediatr Orthop 7:96–99PubMedGoogle Scholar
  9. 9.
    Heyden G, Kindbloom LG, Nielsen JM (1977) Disappearing bone disease: a clinical and histological study. J Bone Joint Surg [Am] 59:57–61Google Scholar
  10. l0.
    Jackson JBS (1838) A boneless arm. Boston Med Surg J 18:368–369Google Scholar
  11. 11.
    Johnson PM, McClure JG (1958) Observations on massive osteolysis. Radiology 71:28–42PubMedGoogle Scholar
  12. 12.
    Kulenkammpff HA, Richter GM, Hasse WE, Adler CP (1990) Massive pelvic osteolysis in the Gorham-Stout syndrome. Int Orthop 14:361–366PubMedGoogle Scholar
  13. 13.
    Leriche R (1937) À propos des osteolyses d'origine indeterminée. Mem Acad Chir 63:419–421Google Scholar
  14. 14.
    Ohnishi T, Kano Y, Nakazawa M, Sakuda M (1993) Massive osteolysis of the mandible. J Oral Maxillofac Surg 51:932–934PubMedGoogle Scholar
  15. 15.
    Pirier H (1968) Massive osteolysis of the humerus treated by resection and prosthetic placement. J Bone Joint Surg [Br] 50:158–160Google Scholar
  16. 16.
    Porter KB, O'Brien WF, Towsley G, Cates JD, Watts DB (1993) Pregnancy complicated by Gorham disease. Obstet Gynecol 81:808–810PubMedGoogle Scholar
  17. 17.
    Schiel H, Prein J (1993) Seven-year follow up of vanishing bone disease in a 14-year-old girl. Head Neck 15:352–356PubMedGoogle Scholar
  18. 18.
    Thompson JS, Schurman DJ (1974) Massive osteolysis. Clin Orthop 103: 206–211PubMedGoogle Scholar
  19. 19.
    Torg JS, Steel HH (1969) Sequential roentgenographic changes occurring in massive osteolysis. J Bone Joint Surg [Am] 51:1649–1655Google Scholar
  20. 20.
    Woodward HR, Chan DPK, Lee J (1981) Massive osteolysis of the cervical spine: a case report of bone graft failure. Spine 6:545–549PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • K. Sato
    • 1
  • S. Yamamura
    • 1
  • H. Sugiura
    • 2
  • T. Mieno
    • 3
  • T. Nagasaka
    • 4
  • N. Nakashima
    • 4
  1. 1.Department of OrthopaedicsNagoya University School of MedicineShowa-ku, NagoyaJapan
  2. 2.Division of OrthopaedicsNagoya Memorial HospitalNagoyaJapan
  3. 3.Division of OrthopaedicsShinshiro Municipal HospitalJapan
  4. 4.Division of Clinical LaboratoryNagoya University HospitalNagoyaJapan

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