A case-control study of cancer mortality at a transformer-assembly facility

  • Sander Greenland
  • Alberto Salvan
  • David H. Wegman
  • Marilyn F. Hallock
  • Thomas J. Smith
Original Article


To address earlier reports of excess cancer mortality associated with employment at a large transformer manufacturing plant, each plant operation was rated for seven exposures: Pyranol (a mixture of poly chlorinated biphenyls and trichlorobenzene), trichloroethylene, benzene, mixed solvents, asbestos, synthetic resins, and machining fluids. Site-specific cancer deaths among active or retired employees were cases; controls were selected from deaths (primarily cardiovascular deaths) presumed to be unassociated with any of the study exposures. Using job records, we then computed person-years of exposure for each subject. All subjects were white males. The only unequivocal association was that of resin systems with lung cancer (odds ratio = 2.2 at 16.6 years of exposure, P = 0.001, in a multiple logistic regression including asbestos, age, year of death, and year of hire). Certain other odds ratios appeared larger, but no other association was so robust and remained as distinct after considering the multiplicity of comparisons. Study power was very limited for most associations, and several biases may have affected our results. Nevertheless, further investigation of synthetic resin systems of the type used in the study plant appears warranted.

Key words

Asbestos Cancer mortality Polychlorinated biphenyls Solvents Transformer assembly Synthetic resins 


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  1. 1.
    Percy C, Stanek E, Gloecker L (1981) Accuracy of death certificates and its effects on cancer mortality statistics. Am J Public Health 71:242–250Google Scholar
  2. 2.
    Greenland S, Salvan A (1990) Report to General Electric on Cancer Mortality at G.E. Pittsfield, Chapter III and Appendices I–VIII. Environmental Science and Technology Dept., General Electric, Fairfield, CT 06431Google Scholar
  3. 3.
    Salvan A (1990) Occupational exposures and cancer mortality at an electrical manufacturing plant: a case-control study. PhD Dissertation. University Microfilms, Ann ArborGoogle Scholar
  4. 4.
    Rom WN (ed) (1992) Environmental and occupational medicine, 2nd edn. Little Brown, BostonGoogle Scholar
  5. 5.
    Hallock MF, Smith TJ (1990) Report to General on Cancer Mortality at G.E. Pittsfield, Chap. 11. Environmental Science and Technology Dept., General Electric, Fairfield, CT 06431Google Scholar
  6. 6.
    Breslow NE, Day NE (1980) Statistical methods in cancer research, vol 1. The analysis of case-control studies. IARC, LyonGoogle Scholar
  7. 7.
    SERC (1987) EGRET statistical software. Statistics and Epidemiology Research Corporation, SeattleGoogle Scholar
  8. 8.
    Schweder T, Spjotvoll E (1982) Plots of P-values to evaluate many tests simultaneously. Biometrika 69:493–502Google Scholar
  9. 9.
    Thomas DC, Siemiatycki J, Dewar R, Robins J, Goldberg M, Armstrong BG (1985) The problem of multiple inference in studies designed hypotheses. Am J Epidemiol 122:1080–1095Google Scholar
  10. 10.
    Greenland S (1992) A semi-Bayes approach to the analysis of correlated multiple associations, with an application to an occupational cancer-mortality study. Stat Med 11:219–230Google Scholar
  11. 11.
    Thomas DC (1983) Statistical methods for analyzing effects of temporal patterns of exposure on cancer risks. Scand J Work Environ Health 9:353–366Google Scholar
  12. 12.
    I.A.R.C. monographs on the evaluation of the carcinogenic risk of chemicals to humans: polychlorinated biphenyls (1982). In: IARC monographs supplement 4. International Agency for Research on Cancer Lyon, pp 217–219Google Scholar
  13. 13.
    I.A.R.C. monographs on the evaluation of the carcinogenic risk of chemicals to humans (1987) Overall evaluation of carcinogenicity: an update of IARC Monographs volumes 1–42. In: IARC monographs supplement 7. International Agency for Research on Cancer, LyonGoogle Scholar
  14. 14.
    Nicholson WJ (1987) Review of human health effects and carcinogenic risk potential of PCBs. Report to the Special Panel on Occupational Risk of Mortality from Cancer from Exposure to Polychlorinated BiphenylsGoogle Scholar
  15. 15.
    Brandt L (1987) Leukaemia and lymphoma risks derived from solvents. Med Oncol Tumor Pharmacother 4:199–205Google Scholar
  16. 16.
    Smith AH, Shearn VI, Wood R (1989) Asbestos and kidney cancer: the evidence supports a causal association. Am J Ind Med 16:159–166Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Sander Greenland
    • 1
  • Alberto Salvan
    • 1
  • David H. Wegman
    • 2
  • Marilyn F. Hallock
    • 3
  • Thomas J. Smith
    • 4
  1. 1.Department of EpidemiologyUCLA School of Public HealthLos AngelesUSA
  2. 2.Department of Work EnvironmentUniversity of MassachusettsLowellUSA
  3. 3.MIT Environmental Health ScienceCambridgeUSA
  4. 4.Harvard School of Public HealthBostonUSA

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