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Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature

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Eosinophilic granuloma is an uncommon lesion, often self-limiting. A location in the spine is rare; until now, only 35 cases have been reported. MRI is the most effective diagnostic technique, although conventional X-ray can also be useful as a first approach.

Therapy consists of immobilization of the patients, surgery and chemotherapy as required by to the clinical findings of the lesion.

The role of radiotherapy is still controversial.

The authors describe the fourth case of eosinophilic granuloma of the cervical spine with neurological symptoms reported in literature.

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  1. [1]

    Alley RM, MD Sussman: Rapidly progressive eosinophilic granuloma. Spine [Am] 17 (1992) 1517–1519

  2. [2]

    Baber WW, Numaguchi, JM Nadell, F Culicchia, AE Robinson: Eosinophilic granuloma of the cervical spine without vertebra plana. J Comp Tom 11 (1987) 346–349

  3. [3]

    Broadbent V, J Pritchard, E Davies: Spontaneous remission of multisystem histiocitosis X. Lancet 1 (1984) 253–254

  4. [4]

    Burger PC, BW Scheithauer, FS Vogel: Surgical pathology of the nervous system and its coverings (3rd ed) Churchill Livingstone Inc, New York 1991

  5. [5]

    Capanna R, DS Springfield, R Biagini: Direct cortisone injection in eosinophilic granuloma of bone: a preliminary report on 11 patient. J Pediatr Orthoped 5 (1985) 539–542

  6. [6]

    Cohen M, J Zornoza, A Cangir et al: Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. Radiology 136 (1980) 289–293

  7. [7]

    Davidson RI, J Shillito: Eosinophilic granuloma of the cervical spine in children. Pediatrics 45 (1970) 746–752

  8. [8]

    Dickinson D, SM Farhat: Eosinophilic granuloma of the cervical spine. Surg Neurol 35 (1991) 57–63

  9. [9]

    Fowles JV, WP Bobechko: Solitary eosinophilic granuloma in bone. J Bone Joint Surg 52B (1970) 238–243

  10. [10]

    Gangemi M, M Mayer, C Sainte-Rose, F Maiuri: Spinal cord compression by an eosinophilic granuloma. J Neurosurg Sci 29 (1985) 117–121

  11. [11]

    Green NE, WW Robertson, AW Kilroy: Eosinophilic granuloma of the spine with associated neural deficit. Report of three cases. J Bone Joint Surg 62 (1980) 1198–1202

  12. [12]

    Green WT, S Farber: “Eosinophilic or solitary granuloma of bone”. J Bone Joint Surg 24 (1942) 499–526

  13. [13]

    Haggstrom JA, JC Brown, PW Marsh: Eosinophilic granuloma of the spine: MR demonstration. J Comput Assist Tomogr 12 (1988) 344–345

  14. [14]

    Harmon DC: Chemotherapy. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds) Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990

  15. [15]

    Hatcher CH: Eosinophilic granuloma of bone. Arch Pathol 30 (1949) 69–76

  16. [16]

    Huvos AG: Bone Tumors Diagnosis, treatment and prognosis. (2nd ed) WB Saunders, Philadelphia 1991

  17. [17]

    Johnson S, T Klostermeier, A Weinstein: Case report 768. Skeletal Radiology 22 (1993) 63–65

  18. [18]

    Lichtenstein L: Histiocitosis X. Integration of eosinophilic granuloma of bone, “Letterer-Siwe disease” and “Schuller-Christian disease” as related manifestation of a single nosologic entity. Arch Pathol 56 (1953) 84–102

  19. [19]

    Lichtenstein L, HI Jaffe: Eosinophilic granuloma of bone with report of a case. Am J Pathol 16 (1940) 595–604

  20. [20]

    Macnab GH: Discussion: eosinophilic granuloma, Letterer-Siwe disease, Hand-Schuller-Christian disease. Proc R Soc Med 48 (1955) 711–720

  21. [21]

    Mirra J: Bone tumors: diagnosis and treatment. JB Lippincot, Philadelphia 1980

  22. [22]

    Moscinski LC, BK Klein Schmidt-Demasters: Primary eosinophilic granuloma of the frontal lobe: diagnostic use of S-100 protein. Cancer 56 (1985) 284–288

  23. [23]

    Otani S, JC Ehrlich: Solitary granuloma of bone simulating primary neoplasm. Am J Pathol 16 (1940) 479–490

  24. [24]

    Rawlings CE, RH Wilkins: Solitary eosinophilic granuloma of the skull. Neurosurgery 15 (1984) 155–161

  25. [25]

    Ree HJ, ME Kadin: Peanut agglutinin: a useful marker for the detection of histiocytosis X and interdigitating reticulum cells. Cancer 57 (1986) 282–287

  26. [26]

    Reed VC, AU Bresolin, AB Lefeure: Granuloma eosinofilo da coluna cervical com manifestaçao neurologica, liquorica, e radiologica atipica. Arq Neuropsiquiatr 33 (1975) 168–177

  27. [27]

    Rosenblum ML: Comment to Rawlings CE and Wilkins RH. Neurosurgery 15 (1984) 161

  28. [28]

    Sanchez RL, J Llover, A Moreno, E Galito: Symptomatic eosinophilic granuloma of the spine. Orthopedics 7 (1984) 1721–1726

  29. [29]

    Sartoris DJ, BR Parker: Histiocitosis X: rate and pattern of resolution of osseus lesions. Radiology 17 (1984) 48–53

  30. [30]

    Seimon LP: Eosinophilic granuloma of spine. J Pediatr Orthop 1 (1981) 371–376

  31. [31]

    Sherk HH, JT Nicholson, JE Nixon: Vertebra plana and eosinophilic granuloma of the cervical spine of children. Spine 3 (1978) 116–121

  32. [32]

    Slater JM, Swarm: Eosinophilic granuloma of bone. Med Pediatr Oncol 8 (1980) 151–164

  33. [33]

    Sweasey TA, RC Dauser: Eosinophilic granuloma of the cervicothoracic junction. J Neurosurg 71 (1989) 942–944

  34. [34]

    Tomita T: Special considerations in surgery of pediatric spine tomors. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds): Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990

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Scarpinati, M., Artico, M. & Artizzu, S. Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature. Neurosurg. Rev. 18, 209–212 (1995).

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  • Bone tumors
  • cervical spine
  • eosinophilic granuloma
  • spine tumors