Eosinophilic granuloma is an uncommon lesion, often self-limiting. A location in the spine is rare; until now, only 35 cases have been reported. MRI is the most effective diagnostic technique, although conventional X-ray can also be useful as a first approach.
Therapy consists of immobilization of the patients, surgery and chemotherapy as required by to the clinical findings of the lesion.
The role of radiotherapy is still controversial.
The authors describe the fourth case of eosinophilic granuloma of the cervical spine with neurological symptoms reported in literature.
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Alley RM, MD Sussman: Rapidly progressive eosinophilic granuloma. Spine [Am] 17 (1992) 1517–1519
Baber WW, Numaguchi, JM Nadell, F Culicchia, AE Robinson: Eosinophilic granuloma of the cervical spine without vertebra plana. J Comp Tom 11 (1987) 346–349
Broadbent V, J Pritchard, E Davies: Spontaneous remission of multisystem histiocitosis X. Lancet 1 (1984) 253–254
Burger PC, BW Scheithauer, FS Vogel: Surgical pathology of the nervous system and its coverings (3rd ed) Churchill Livingstone Inc, New York 1991
Capanna R, DS Springfield, R Biagini: Direct cortisone injection in eosinophilic granuloma of bone: a preliminary report on 11 patient. J Pediatr Orthoped 5 (1985) 539–542
Cohen M, J Zornoza, A Cangir et al: Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. Radiology 136 (1980) 289–293
Davidson RI, J Shillito: Eosinophilic granuloma of the cervical spine in children. Pediatrics 45 (1970) 746–752
Dickinson D, SM Farhat: Eosinophilic granuloma of the cervical spine. Surg Neurol 35 (1991) 57–63
Fowles JV, WP Bobechko: Solitary eosinophilic granuloma in bone. J Bone Joint Surg 52B (1970) 238–243
Gangemi M, M Mayer, C Sainte-Rose, F Maiuri: Spinal cord compression by an eosinophilic granuloma. J Neurosurg Sci 29 (1985) 117–121
Green NE, WW Robertson, AW Kilroy: Eosinophilic granuloma of the spine with associated neural deficit. Report of three cases. J Bone Joint Surg 62 (1980) 1198–1202
Green WT, S Farber: “Eosinophilic or solitary granuloma of bone”. J Bone Joint Surg 24 (1942) 499–526
Haggstrom JA, JC Brown, PW Marsh: Eosinophilic granuloma of the spine: MR demonstration. J Comput Assist Tomogr 12 (1988) 344–345
Harmon DC: Chemotherapy. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds) Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990
Hatcher CH: Eosinophilic granuloma of bone. Arch Pathol 30 (1949) 69–76
Huvos AG: Bone Tumors Diagnosis, treatment and prognosis. (2nd ed) WB Saunders, Philadelphia 1991
Johnson S, T Klostermeier, A Weinstein: Case report 768. Skeletal Radiology 22 (1993) 63–65
Lichtenstein L: Histiocitosis X. Integration of eosinophilic granuloma of bone, “Letterer-Siwe disease” and “Schuller-Christian disease” as related manifestation of a single nosologic entity. Arch Pathol 56 (1953) 84–102
Lichtenstein L, HI Jaffe: Eosinophilic granuloma of bone with report of a case. Am J Pathol 16 (1940) 595–604
Macnab GH: Discussion: eosinophilic granuloma, Letterer-Siwe disease, Hand-Schuller-Christian disease. Proc R Soc Med 48 (1955) 711–720
Mirra J: Bone tumors: diagnosis and treatment. JB Lippincot, Philadelphia 1980
Moscinski LC, BK Klein Schmidt-Demasters: Primary eosinophilic granuloma of the frontal lobe: diagnostic use of S-100 protein. Cancer 56 (1985) 284–288
Otani S, JC Ehrlich: Solitary granuloma of bone simulating primary neoplasm. Am J Pathol 16 (1940) 479–490
Rawlings CE, RH Wilkins: Solitary eosinophilic granuloma of the skull. Neurosurgery 15 (1984) 155–161
Ree HJ, ME Kadin: Peanut agglutinin: a useful marker for the detection of histiocytosis X and interdigitating reticulum cells. Cancer 57 (1986) 282–287
Reed VC, AU Bresolin, AB Lefeure: Granuloma eosinofilo da coluna cervical com manifestaçao neurologica, liquorica, e radiologica atipica. Arq Neuropsiquiatr 33 (1975) 168–177
Rosenblum ML: Comment to Rawlings CE and Wilkins RH. Neurosurgery 15 (1984) 161
Sanchez RL, J Llover, A Moreno, E Galito: Symptomatic eosinophilic granuloma of the spine. Orthopedics 7 (1984) 1721–1726
Sartoris DJ, BR Parker: Histiocitosis X: rate and pattern of resolution of osseus lesions. Radiology 17 (1984) 48–53
Seimon LP: Eosinophilic granuloma of spine. J Pediatr Orthop 1 (1981) 371–376
Sherk HH, JT Nicholson, JE Nixon: Vertebra plana and eosinophilic granuloma of the cervical spine of children. Spine 3 (1978) 116–121
Slater JM, Swarm: Eosinophilic granuloma of bone. Med Pediatr Oncol 8 (1980) 151–164
Sweasey TA, RC Dauser: Eosinophilic granuloma of the cervicothoracic junction. J Neurosurg 71 (1989) 942–944
Tomita T: Special considerations in surgery of pediatric spine tomors. In: Sundaresan N, HH Schmidek, AL Schiller, DI Rosenthal (eds): Tumors of the spine. Diagnosis and clinical management. WB Saunders, Philadelphia 1990
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Scarpinati, M., Artico, M. & Artizzu, S. Spinal cord compression by eosinophilic granuloma of the cervical spine. Case report and review of the literature. Neurosurg. Rev. 18, 209–212 (1995). https://doi.org/10.1007/BF00383729
- Bone tumors
- cervical spine
- eosinophilic granuloma
- spine tumors