Molecular and General Genetics MGG

, Volume 198, Issue 2, pp 213–220

Polyhomeotic: A gene of Drosophila melanogaster required for correct expression of segmental identity

  • Jean-Maurice Dura
  • Hugh W. Brock
  • Pedro Santamaria
Article

DOI: 10.1007/BF00382998

Cite this article as:
Dura, JM., Brock, H.W. & Santamaria, P. Molec. Gen. Genet. (1985) 198: 213. doi:10.1007/BF00382998

Summary

A new locus in Drosophila melanogaster that is required for the correct expression of segmental identity has been discovered. The new locus, termed polyhomeotic (ph), is X-linked and maps cytologically to bands 2D2-3. Homozygous ph flies have homeotic transformations similar to those of known dominant gain of function mutants in the Antennapedia and bithorax complexes (ANT-C, BX-C), and in addition show loss of the humerus. ph interacts with three other similar mutations: Polycomb (Pc), Polycomblike (Pcl), and extra sex comb (esc), and acts as a dominant enhancer of Pc. The expression of ph depends on the ANT-C and BX-C dosage. ph has no embryonic phenotype, but temperature shift studies on ph2 show that the ph+ product is required during embryogenesis and larval development. We propose that ph mutants in some way disrupt the normal expression of the ANT-C and BX-C, and, therefore, that ph+ is needed for maintenance of segmental identity.

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Jean-Maurice Dura
    • 1
  • Hugh W. Brock
    • 2
  • Pedro Santamaria
    • 1
  1. 1.Centre de Génétique MoléculaireCentre National de la Recherche ScientifiqueGif-sur-YvetteFrance
  2. 2.Department of ZoologyUniversity of British ColumbiaVancouverCanada

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