The removal of pyrimidine dimers from deoxyribonucleic acid of ultraviolet irradiated cultures of Neisseria gonorrhoeae can not be readily ascertained by using radioactively labeled thymidine percursors. However, by adapting the alkaline agarose gel technique of Achey et al. (Photochem Photobiol 29, 305–310, 1979), it was possible to demonstrate that this human pathogen does possess an active excision repair system that functions on pyrimidine dimers.
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This work was performed as partial fulfillment for a Doctoral Thesis by L.A. Campbell.
Communicated by G.A. O'Donovan
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Campbell, L.A., Yasbin, R.E. A DNA excision repair system for Neisseria gonorrhoeae . Molec. Gen. Genet. 193, 561–563 (1984). https://doi.org/10.1007/BF00382101
- Excision Repair
- Human Pathogen