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On the value of 5-aminolevulinic acid dehydratase activity as predictor for lead in blood

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Summary

In 222 females lead in blood (PbB) and 5-aminolevulinic acid dehydratase activity (ALA-D) were measured. PbB ranged from 40 to 240 ppb. The measurement error (precision) of PbB-determination was 18ppb. The error in predicting actual lead in blood from ALA-D amounted to 32 ppb. This could be ascribed to biological variation and insufficient specificity of ALA-D for lead in blood. It is concluded that ALA-D as predictor for lead in blood can only be used:

  1. 1.

    for group monitoring

  2. 2.

    as rough measure for lead in blood in individual cases at low levels of lead exposure.

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References

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Herber, R.F.M., Sallé, H.J.A. On the value of 5-aminolevulinic acid dehydratase activity as predictor for lead in blood. Int. Arch Occup Environ Heath 41, 147–150 (1978). https://doi.org/10.1007/BF00381799

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Key words

  • Lead-in-blood
  • ALA-D