Environmental and biological monitoring of non-occupational exposure to 1,3-dichloropropene

  • R. T. H. van Welie
  • P. van Duyn
  • N. P. E. Vermeulen
Article
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Summary

Voluntary bystanders, simulating a situation of non-occupational exposure to Z- and E-1,3-dichloropropene (Z- and E-DCP), were exposed during field application of this nematocide in the Dutch flower-bulb culture. Environmental monitoring revealed that mean respiratory exposure concentrations of Z- and E-DCP varied from non-detectable levels to 1.12 mg/m3 8-h time-weighted average (TWA) for Z-DCP and to 0.91 mg/m3 8-h TWA for E-DCP. Biological monitoring was executed by determining urinary mercapturic acid metabolites of Z- and E-DCP according to a method recently validated in occupationally exposed applicators. A linear relationship between respiratory exposure to Z-and E-DCP and the urinary excretion of both mercapturic acids was observed in bystanders. Dermal uptake did not contribute significantly to the internal dose of Z- or E-DCP. The urinary mercapturic acid of Z-DCP was a more sensitive parameter for the detection of exposure than was respiratory air monitoring. In future studies it would be worthwhile to determine the extent of exposure of real bystanders to DCP on the basis of urinary mercapturic acid excretion.

Key words

Mercapturic acids Non-occupational exposure 1,3-Dichloropropene Environmental monitoring Biological monitoring 
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References

  1. Brouwer DH, Brouwer EJ, Vreede JAF de, Welie RTH van, Vermeulen NPE, Hemmen JJ van (1991) Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture: I. Environmental monitoring. Arch Environ Contam Toxicol 20:1–5Google Scholar
  2. Brouwer EJ, Evelo CIA, Verplanke AJW, Welie RTH van, Wolff FA de (1991) Biological effect monitoring of occupational exposure to 1,3-dichloropropene: effects on liver and renal function and on glutathione conjugation. Br J Ind Med 48:167–172Google Scholar
  3. Buurveld HA, Dost H, Hoorn R van der (1988) Grondontsmettingsmiddelen en hun verspreiding door de lucht. (in Dutch) In: Serie studentenverslagen 39. Interfacultaire Vakgroep Energie en Milieukunde, Rijksuniversiteit van GroningenGoogle Scholar
  4. Frank R, Campbell RA, Sirons GJ (1985) Forestry workers involved in aerial application of 2,4-dichlorophenoxyacetic acid (2,4-D): exposure and urinary excretion. Arch Environ Contam Toxicol 14:427–435Google Scholar
  5. Hill RH, To T, Holler JS, Fast DM, Smith SJ, Needham LL, Binder S (1989) Residues of chlorinated phenols and phenoxy acid herbicides in the urine of Arkansas children. Arch Environ Contam Toxicol 18:469–474Google Scholar
  6. Hsu P, Wheeler HG, Camann DE, Schattenberg HJ, Lewis RG, Bond AE (1988) Analytical methods for detection of nonoccupational exposure to pesticides. J Chromatogr Sci 26:181–189Google Scholar
  7. Lewis RG, Bond AE, Fitz-Simons TR, Johnson DE, Hsu JP (1986) Monitoring for non-occupational exposure to pesticides in indoor and personal respiratory air. Presented at the 79th annual meeting of the Air Pollution Control Association, Minneapolis, Minnesota, June 22–27Google Scholar
  8. Matsumura F, Madhukar BV (1980) Exposure to pesticides. Pharmacol Ther 9:27–49Google Scholar
  9. MJPG (1990) Beleidssamenvatting meerjarenplan gewasbescherming. In: Meerjarenplan Gewasbescherming (in Dutch). Ministerie van Landbouw, Natuurbeheer en Visserij, Den HaagGoogle Scholar
  10. Ohe T (1979) Pentachlorophenol residues in human adipose tissue. Bull Environ Contam Toxicol 22:287–292Google Scholar
  11. Onkenhout W, Mulder PPJ, Boogaard PJ, Buys W, Vermeulen NPE (1986) Identification and quantitative determination of mercapturic acids formed from Z- and E-1,3-dichloropropene by the rat, using gas chromatography with three different detection techniques. Arch Toxicol 59:235–241Google Scholar
  12. Osterloh JD, Wang R, Schneider S, Maddy K (1989) Biological monitoring of dichloropropene: air concentrations, urinary metabolite, and renal enzyme excretion. Arch Environ Health 44:207–213Google Scholar
  13. Sangster B, Wegman RCC, Hofstee AWM (1982) Non-occupational exposure to pentachlorophenol: clinical findings and plasma-PCP concentrations in three families. Hum Toxicol 1:123–133Google Scholar
  14. Vos RME, Welie RTH van, Peters WHM, Evelo CTA, Boogaards JJP, Vermeulen NPE, Bladeren PJ van (1991) Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of mercapturic acids of Z- and E-1,3-dichloropropene. Arch Toxicol 65:95–99Google Scholar
  15. VROM (1988) Ministerie van Valkshuisvesting, Ruimtelijke Ordening en Milieubeheer, Den Haag. Bijlage bij de antwoorden op de vragen van de Leden der Kramer Eisma en Tommel over concentraties van dichloorpropeen en methylisothiocyanaat in de lucht. (in Dutch) Publication 2888901550Google Scholar
  16. Welie RTH van, Duyn P van, Vermeulen NPE (1989) Determination of two mercapturic acid metabolites of 1,3-dichloropropene in human urine with gas chromatography and sulphur-selective detection. J Chromatogr 496:463–471Google Scholar
  17. Welie RTH van, Duyn P van, Brouwer DH, Hemmen JJ van, Brouwer EJ, Vermeulen NPE (1991) Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture: II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites. Arch Environ Contam Toxicol 20:6–12Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • R. T. H. van Welie
    • 1
  • P. van Duyn
    • 1
  • N. P. E. Vermeulen
    • 1
  1. 1.Department of Pharmacochemistry, Division of Molecular ToxicologyFree UniversityAmsterdamThe Netherlands

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