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Replacement of epiphyseal bone with methylmethacrylate: Its effect on articular cartilage

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Methylmethacrylate cement was used as a substitute for the epiphyseal bone of the canine proximal femora, after femoral neck osteotomy. The effects of different volumes of acrylic cement on the integrity of trabecular bone and articular cartilage and the effects of different types of fixation of the osteotomy site were assessed clinically, radiologically and histologically. Degenerative changes occurring in the articular cartilage were greatest when a large area of epiphyseal bone was replaced with methylmethacrylate. These degenerative changes varied proportionately with the rigidity of fixation at the osteotomy site. Rigid fixation resulted in a better clinical and radiographic assessment and a decrease in histopathologic changes in the articular cartilage.


Methakrylat-Zement wurde als Ersatz für die proximale Femurepiphyse beim Hund nach Schenkelhalsosteotomie verwendet. Die Auswirkungen verschiedener Mengen des MethakrylatZements auf die Unversehrtheit der trabekulären Knochenstruktur und des Gelenkknorpels und der Effekt der verschiedenen Arten der Fixation der Ostetomie wurden klinisch, radiographisch and histologisch untersucht. Die stärksten degenerativen Veränderungen in dem Gelenkknorpel wurden beobachtet, wenn ein ausgedehnter Bereich der Epiphyse durch Methakrylat ersetzt wurde. Diese degenerativen Veränderungen variierten proportional zu der Starrheit der Osteosynthese an der Osteotomiestelle. Eine starre Fixation ergab eine bessere klinische und radiographische Beurteilung der Knochenstruktur und geringere histologische Veränderungen des Gelenkknorpels.

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Correspondence to Paul A. Manley DVM, MSc.

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Supported by University of Guelph Advisory Board Research Grant

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Manley, P.A., McKeown, D.B., Schatzker, J. et al. Replacement of epiphyseal bone with methylmethacrylate: Its effect on articular cartilage. Arch. Orth. Traum. Surg. 100, 3–10 (1982).

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  • Public Health
  • Femoral Neck
  • Articular Cartilage
  • Trabecular Bone
  • Degenerative Change