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Early indicators of renal damage in workers exposed to organic solvents

  • I. Franchini
  • A. Cavatorta
  • M. Falzoi
  • S. Lucertini
  • A. Mutti
Original Papers

Summary

In order to investigate the renal function, a cross-sectional study was carried out on four groups of workers significantly exposed to a mixture of alicyclic and aliphatic C5-C7 hydrocarbons, to styrene, to a mixture mostly composed of toluene and xylenes and to chlorinated hydrocarbons, respectively. The study involved 438 workers. Exposure was characterized by means of urinary metabolites, or by means of environmental measures, when biological indicators were not available. The renal function impairment indicators included total proteinuria, albuminuria and urinary excretion of muramidase (E.C. 3.2.1.17) and beta-glucuronidase (E.C. 3.2.1.31). The trend of these parameters provides some evidence of renal damage due to occupational exposure to organic solvents and suggests that the lesions are mild and tubular rather than glomerular.

Key words

Nephrotoxicity Solvents Kidney tubules Hydrocarbons Styrene Toluene Xylenes Perchloroethylene 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • I. Franchini
    • 1
  • A. Cavatorta
    • 1
  • M. Falzoi
    • 1
  • S. Lucertini
    • 1
  • A. Mutti
    • 1
  1. 1.Institute of “Semeiotica Medica”, Chair of Occupational MedicineUniversity of ParmaParma PRItaly

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