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Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene


The urinary excretion of 3,4-dimethylhippuric acid (34DMHA), a 1,2,4-trimethylbenzene (124TMB) metabolite, was investigated in workers exposed to 124TMB vapor. The time-weighted average of exposure to 124TMB was determined with a diffusive sampler. For biological monitoring of exposure, urine samples were collected from individual workers and analyzed for metabolites by high-pressure liquid chromatography. The concentration of urinary 34DMHA had a positive correlation with the level of exposure to 124TMB (r = 0.72). The data suggest that 34DMHA is one of the useful indicators for biological monitoring of 124TMB exposure.

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Correspondence to Masayoshi Ichiba.

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Ichiba, M., Hama, H., Yukitake, S. et al. Urinary excretion of 3,4-dimethylhippuric acid in workers exposed to 1,2,4-trimethylbenzene. Int. Arch Occup Environ Heath 64, 325–327 (1992). https://doi.org/10.1007/BF00379541

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Key words

  • Trimethylbenzene
  • Urinary metabolite
  • Dimethylhippuric acid
  • Biological monitoring