Determination and prediction of tissue-gas partition coefficients

  • Vera Fiserova-Bergerova
  • Maria L. Diaz
Original Papers


The head space method for determination of tissue-gas partition coefficients was modified to make it suitable for determination of tissue-gas partition coefficients of water soluble solvents. The method was used to determine tissue-gas partition coefficients of acetone, 2-butanone, methanol, ethanol, 1-propanol, 2-propanol and isobutanol for six representative tissues (muscle, kidney, lung, white and gray matter of brain, and adipose tissue). Blood-gas partition coefficients and distribution between plasma and erythrocytes were also determined. Relation between tissue-blood and fat-blood partition coefficients of 35 hydrophilic and hydrophobic substances of different chemical structure is described by linear correlation equations which can be used for prediction of tissue-gas partition coefficients of any chemical for which blood-gas and fat-gas partition coefficients are known. The correlation equations are based on all currently available data.

Key words

Partition coefficients: Tissue/gas Blood/gas Hydrophilic solvents Method for determination Correlation equations 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Vera Fiserova-Bergerova
    • 1
  • Maria L. Diaz
    • 1
  1. 1.Department of AnesthesiologyUniversity of Miami School of MedicineMiamiUSA

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