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The Science of Nature

, Volume 75, Issue 5, pp 247–251 | Cite as

The endocrinology of sunlight and darkness

Complementary roles of vitamin D and pineal hormones
  • Walter E. Stumpf
Article

Conclusions

While the term “vitamin D” can not be found in recent monographs and conference proceedings on pineal functions and while considerations of pineal hormone involvement are absent in reviews of vitamin D hormonal actions, strong evidence exists for extensive effects of the skin-vitamin D message beyond calcium metabolism and of the eye-pineal hormone actions beyond reproduction. New evidence from our histochemical studies on 1,25(OH)2 vitamin D3 sites of action, together with other reinterpreted evidence, testifies to the general importance of the skin-vitamin D and eye-pineal systems as well as to close interrelationships between these two endocrine systems. Both appear to have common targets, and effects of their messsages are antagonistic or complementary in the regulation and modulation of biological functions in tune with our solar environments.

The present concept will be illuminating for our understanding of the photobiological effects of light and related human annual cyclicity [29], involving birth rate, growth rate, carbohydrate tolerance and incidence of insulin-dependent diabetes [27], incidence of menarche, hemoglobin and hormone levels, mortality and suicide, as well as seasonal affective disorder [30]. In all of these and other seasonal conditions, the causative involvement of skin-mediated vitamin D-soltriol should be considered. Absence or presence, that is, the degree of soltriol somatotrophic activation, appears to be the most important determinant in the etiology and therapy of biological events related to light and darkness. Effects of the vitamin D-related activation through the short-wave component of light or through nutrition may be limited, however, since the darknessrelated production of pineal hormone(s) may not be eliminated by short-wave light or soltriol treatment alone. Concurrently with skin exposure to ultraviolet light or treatment with the hormone of light, the effects of the hormone of darkness may need to be curtailed by optic exposure to visible light or by treatment with an antagonist to pineal hormone.

Keywords

Melatonin Endocrine System Pineal Gland Calcium Metabolism Triol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Huldschinsky, K.: Klin. Wschr. 26, 712 (1919)CrossRefGoogle Scholar
  2. 2.
    Windaus, A., Schenck, F., von Weder, F.: Hoppe-Seylers Z. Physiol. Chem. 241, 100 (1936)CrossRefGoogle Scholar
  3. 3.
    Holick, M. F., et al.: Biochemistry 10, 2799 (1971); Norman, A. W.: J. Clin. Nutr. 24, 1346 (1971)CrossRefPubMedGoogle Scholar
  4. 4.
    Norman, A. W., Roth, J., Orci, L.: Endocr. Rev. 3, 331 (1982); DeLuca, H. F., in: Vitamin D. Basic and Clinical Aspects, p. 1 (Kumar, R., ed.). Dordrecht: Nijhoff 1984; Hausler, M. R.: Ann. Rev. Nutr. 6, 527 (1986)CrossRefPubMedGoogle Scholar
  5. 5.
    Stumpf, W. E., O'Brien, L. P.: Histochemistry 87, 393 (1987); Stumpf, W. E., Sar M., O'Brien, L. P.: ibid. 88, 11 (1987); Stumpf, W. E., et al.: Anat. Embryol. 177, 307 (1988); Stumpf, W. E.: Histochemistry 89, 209 (1988)CrossRefPubMedGoogle Scholar
  6. 6.
    Kappers, J. A.: Progr. Brain Res. 52, 3 (1979); Oksche, A., Hartwig, H.-G.: ibid. 52, 113 (1979); Vollrath, L., in: Handbuch der mikroskopischen Anatomie des Menschen, Vol. VI/7 (Oksche, A., Vollrath, L., eds.). Berlin: Springer 1981; Relkin, R. (ed.): The Pineal Gland. Amsterdam: Eisevier Biomedical 1983; Reiter, R. J. (ed.): The Pineal Gland. New York: Raven 1984; Brown, G. M., Wainwright, S. D. (eds.): The Pineal Gland: Endocrine Aspects. New York: Pergamon 1985CrossRefGoogle Scholar
  7. 7.
    Stumpf, W. E.: Neuroendocrinol. Lett. (in press)Google Scholar
  8. 8.
    Stumpf, W. E., Roth, L. J.: J. Histochem. Cytochem. 14, 274 (1966); Stumpf, W. E.: Science 162, 1001 (1968); Stumpf, W. E., in: Methods in Cell Biology, Vol. XIII, p. 171 (Prescott, D. M., ed.). New York: Academic Press 1976CrossRefPubMedGoogle Scholar
  9. 9.
    Stumpf, W. E., et al.: Science 206, 1188 (1979); Stumpf, W. E., et al.: Neuroendocrinol. Lett. 2, 297 (1980); Stumpf, W. E., et al.: Science 215, 1404 (1982)CrossRefPubMedGoogle Scholar
  10. 10.
    Sar, M., Stumpf, W. E., DeLuca, H. F.: Cell Tiss. Res. 209, 161 (1980); Sar, M., Miller, W. E., Stumpf, W. E.: Physiologist 24, 70 (1981)CrossRefGoogle Scholar
  11. 11.
    Stumpf, W. E., et al.: Cell Tiss. Res. 238, 489 (1984)CrossRefGoogle Scholar
  12. 12.
    Stumpf, W. E., et al.: ibid. 221, 333 (1981); Stumpf, W. E., O'Brien, L. P.: Histochemistry 87, 53 (1987)CrossRefGoogle Scholar
  13. 13.
    Clark, S. A., et al.: Cell Tiss. Res. 209, 515 (1980); Clark, S. A., Stumpf, W. E., Sar, M.: Diabetes 30, 382 (1981)CrossRefGoogle Scholar
  14. 14.
    Stumpf, W. E., et al.: Histochemistry (in press)Google Scholar
  15. 15.
    Clark, S. A., et al.: Cell Tiss. Res. 234, 299 (1986)Google Scholar
  16. 16.
    Stumpf, W. E., et al.: Proc. Nat. Acad. Sci. USA 77, 1149 (1980)CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Stumpf, W. E., et al.: Cell Tiss. Res. 247, 453 (1987)CrossRefGoogle Scholar
  18. 18.
    Stumpf, W. E., Downs, T. W.: Histochemistry 87, 367 (1987)CrossRefPubMedGoogle Scholar
  19. 19.
    Kim, Y. S., et al.: J. Dent. Res. 62, 58 (1983); Clark, S. A., et al.: Anat. Rec. 212, 250 (1985)CrossRefPubMedGoogle Scholar
  20. 20.
    Stumpf, W. E., Sar, M., in: Receptors and Mechanism of Action of Steroid Hormones, p. 41 (Pasqualini, J., ed.). New York: Dekker 1976; Stumpf, W. E., in: Interactions between the Nervous and the Endocrine Systems, p. 103 (Verhofstad, A. A. J., van Kemenade, J. A. M., eds.). University of Nijmegen 1979Google Scholar
  21. 21.
    Holick, M. F., in: Vitamin D. Basic and Clinical Aspects, p. 197 (Kumar, R., ed.). Dordrecht: Nijhoff 1984Google Scholar
  22. 22.
    Stumpf, W. E., Sar, M.: Exp. Brain Res., Suppl. 3, 18 (1981)CrossRefGoogle Scholar
  23. 23.
    Loomis, W. F.: Science 157, 501 (1967); Hosomi, J., et al.: Endocrinology 113, 1950 (1983); Marx, S. J., in: Vitamin D. Basic and Clinical Aspects, p. 721 (Kumar, R., ed.). Dordrecht: Nijhoff 1984CrossRefPubMedGoogle Scholar
  24. 24.
    Lerner, A. B., et al.: J. Am. Chem. Soc. 80, 2587 (1958)CrossRefGoogle Scholar
  25. 25.
    Aksnes, L., Aarskog, D.: J. Clin. Endocrinol. Metab. 55, 94 (1982); Clark, S. A., Boass, A., Toverud, S. U.: Bone Mineral. 1, 193 (1986)CrossRefPubMedGoogle Scholar
  26. 26.
    Baschieri, L., et al.: Experientia 19, 15 (1963); Houssay, A. B., Pazo, J. H.: ibid. 24, 813 (1968); Panda, J. N., Turner, C. W.: Acta Endocrinol. 57, 363 (1968); Csaba, G., Nagy, S. U.: Acta biol. med. germ. 31, 617 (1973); DeFronzo, R. A., Roth, W. D.: Acta Endocrinol. 70, 31 (1972); Vriend, J., et al.: Neuroendocrinology 35, 79 (1982)CrossRefPubMedGoogle Scholar
  27. 27.
    Relkin, R., in: The Pineal Gland, pp. 225, 247 (Relkin, R., ed.). Amsterdam: Elsevier Biomedical 1983; Karasek, M., Reiter, R. J.: Med. Hypoth. 9, 1 (1982); Wetterberg, L.: Prog. Brain Res. 52, 539 (1979); Houssay, A. B., Pazo, J. H., Epper, C. E.: J. Invest. Dermatol. 47, 230 (1966); MacDonald, M. J., et al.: Diabetes 36, 265 (1987)Google Scholar
  28. 28.
    Conrad, C. D., Stumpf, W. E., in: Anatomical Neuroendocrinology, p. 15 (Stumpf, W. E., Grant, L. D., eds.). Basel: Karger 1975Google Scholar
  29. 29.
    Aschoff, J., in: Handbook of Behavioral Neurobiology, Vol. 4, p. 475 (Aschoff, J., ed.). New York: Plenum 1981Google Scholar
  30. 30.
    Lewy, A. J., Sack, R. L., Singer, C. L.: Psychopharm. Bull. 20, 561 (1984); Rosenthal, N. E., et al.: Ann. N.Y. Acad. Sci. 453, 260 (1985); Jacobsen, F. M., et al.: Am. J. Publ. Health 77, 57 (1987)Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Walter E. Stumpf
    • 1
  1. 1.Departments of Cell Biology and Anatomy and of PharmacologyUniversity of North Carolina Medical SchoolChapel HillUSA

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