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Immunogenetics

, Volume 23, Issue 2, pp 126–128 | Cite as

HLA-DQβ chain DNA restriction fragments can differentiate between healthy and narcoleptic individuals with HLA-DR2

  • Hidetoshi Inoko
  • Asako Ando
  • Kimiyoshi Tsuji
  • Kazumasa Matsuki
  • Takeo Juji
  • Yutaka Honda
Brief Communications

Keywords

Restriction Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Benacerraf, B.: Role of MHC gene products in immune regulation. Science 212: 1229–1238, 1981Google Scholar
  2. Cohen, D., Le Gall, I., Marcadet, A., Font, M.-P., Lalouel, J.-M., and Dausset, J.: Clusters of HLA class IIβ restriction fragments describe allelic series. Proc. Natl. Acad. Sci. U.S.A. 81: 7870–7874, 1984Google Scholar
  3. Dausset, J. and Svejgaard, A. (eds.): In: HLA and Disease, Munksgaard. Copenhagen, 1977Google Scholar
  4. Honda, Y., Doi, Y., Juji, T., and Satake, M.: Narcolepsy and HLA-positive DR2 as a prerequisite for the development of narcolepsy. Folia Psychiatr. Neurol. Jpn. 38: 360, 1984Google Scholar
  5. Inoko, H., Ando, A., Kimura, M., Ogata, S., and Tsuji, K.: Isolation and characterization of the cDNA clone and genomic clones of the HLA class II antigen heavy chains. In E. D. Albert, M. P. Baur, and W. R. Mayr (eds.): Histocompatibility Testing 1984, pp. 559–564, Springer-Verlag, Berlin, 1984Google Scholar
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  7. Inoko, H., Ando, A., Kimura, M., and Tsuji, K.: Isolation and characterization of the cDNA clones and genomic clones of the HLA class II antigens. Proceedings of the Twentieth Japan Transplantation Society Symposium, pp. 188–220, Tokai University Press, Tokyo, 1985bGoogle Scholar
  8. Juji, T., Satake, M., Honda, Y., and Doi, Y.: HLA antigens in Japanese patients with narcolepsy. Tissue Antigens 24: 316–319, 1984Google Scholar
  9. Langdon, N., Welsh, K. I., Dam, M. V., Vaugham, R. W., and Parkes, D.: Genetic markers in narcolepsy. Lancet ii: 1178–1180, 1984Google Scholar
  10. Matsuki, M., Juji, T., Tokunaga, K., Naohara, T., Satake, M., and Honda, Y.: HLA haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics. J. Clin. Invest., in press, 1985Google Scholar
  11. Owerbach, D., Lernmark, Å., Rask, L., Peterson, P. A., Platz, P., and Svejgaard, A: Detection of HLA-D/DR-related DNA polymorphism in HLA-D homozygous typing cells. Proc. Natl. Acad. Sci. U.S.A. 80: 3758–3761, 1983Google Scholar
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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Hidetoshi Inoko
    • 1
  • Asako Ando
    • 1
  • Kimiyoshi Tsuji
    • 1
  • Kazumasa Matsuki
    • 2
  • Takeo Juji
    • 2
  • Yutaka Honda
    • 3
  1. 1.Department of Transplantation, School of MedicineTokai UniversityIsehara, KanagawaJapan
  2. 2.Blood Transfusion ServiceTokyo University HospitalTokyoJapan
  3. 3.Neuropsychiatric Research FoundationSeiwa HospitalShinjuku-ku, TokyoJapan

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