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Effect of exposure to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide on rabbit lung

A light and electron microscopic study
  • C. Hugod
Article

Summary

Continuous exposure of rabbits to 43 ppm nitric oxide and 3.6 ppm nitrogen dioxide for 6 days did not cause morphological changes in the lungs when compared to specimens from nonexposed rabbits. This is not in accordance with previously reported findings.

Key words

Nitric oxide (NO) Nitrogen dioxide (NO2Rabbit lung Histotoxicity Artefacts 

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References

  1. 1.
    Bone, Q., Ryan, K. P.: Osmolarity of osmium tetroxide and glutaraldehyde fixatives. In: Fixation in Histochemistry, (P. J. Stoward, ed). pp. 85–101. London: Chapman and Hall 1973Google Scholar
  2. 2.
    Ehrlich, R.: Effect of nitrogen dioxide on resistance to respiratory infection. Bacteriol. Rev. 30, 604–614 (1966)Google Scholar
  3. 3.
    Harrison, G. D., Solomon, J. D.: Ultrastructural alterations observed in mouse lung after prolonged He/O2 exposure. Aviat. Space Environ. Med. 46, 21–25 (1975)Google Scholar
  4. 4.
    Haudenschild, D., Baumgarten, H. R., Studo, A.: Significance of fixation procedure for preservation of arteries. Experientia 28, 828–831 (1972)Google Scholar
  5. 5.
    Hopwood, D.: Theoretical and practical aspects of glutaraldehyde fixation. In: Fixation in Histochemistry (P. J. Stoward, ed.), pp. 47–83. London: Chapman and Hall 1973Google Scholar
  6. 6.
    Hugod, C.: Ultrastructural changes of the rabbit lung after a 5 ppm nitric oxide exposure. Arch. Environ. Health (1978) (in press)Google Scholar
  7. 7.
    Kistler, G. S., Caldwell, P. R. B., Weibel, E. R.: Quantitative electron microscopic studies of murine lung damage after exposure to 98.5 % oxygen at ambient pressure: A preliminary report. In: Hyperbaric medicine, Proc. 3. International Conference on Hyperbaric Medicine, National Res. Council Publ. no 1404 (1966)Google Scholar
  8. 8.
    Nieding, G. von, Wagner, H. M., Krekeler, H.: Investigation of the acute effects of nitrogen monoxide on lung function in mouse. In: Proceedings of the Third International Clean air Congress, pp. A 14–16. Düsseldorf: Verlag des Vereins Deutscher Ingenieure 1973Google Scholar
  9. 9.
    Oda, H., Kusumoto, S., Nakajima, T.: Nitrosyl-hemoglobin formation in the blood of animals exposed to nitric oxide. Arch. Environ. Health 30, 453–456 (1975)Google Scholar
  10. 10.
    Schwartz, L. W., Dungworth, D. L., Mustafa, M. G., Torkington, B. K., Tyler, W. S.: Pulmonary responses of rats to ambient levels of ozone. Lab. Invest. 34, 565–578 (1976)Google Scholar
  11. 11.
    Stephens, R. J., Freeman, G., Evans, M. J.: Early response of lungs to low level of nitrogen dioxide. Arch. Environ. Health 24, 160–179 (1972)Google Scholar
  12. 12.
    York, G. K., Peirce, T. H., Schwartz, L. W., Cross, C. E.: Stimulation by cigarette smoke of glutathione peroxidase system enzyme activities in rat lung. Arch. Environ. Health 31, 286 290 (1976)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • C. Hugod
    • 1
  1. 1.Department of Clinical ChemistryRigshospitaletCopenhagenDenmark

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