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Experimental human exposure to carbon disulfide

I. Respiratory uptake and elimination of carbon disulfide under rest and physical exercise

Summary

Six human volunteers were exposed to 10 and 20 ppm carbon disulfide at rest and to 3 and 10 ppm carbon disulfide under a 50 W level of physical exercise during four consecutive periods of 50 min. Every 5 min a sample was taken from the mixed exhaled air in which the concentration of carbon disulfide was determined. It was established that only an apparent steady state was reached during this exposure period. The retention values were established as 0.374 (SD = 0.106; n = 239) for exposure to 10 ppm carbon disulfide at rest and as 0.410 (SD = 0.103; n = 239) for exposure to 20 ppm carbon disulfide at rest. During exposure to 10 ppm and 3 ppm carbon disulfide, combined with a 50 W level of physical exercise, the retention values decreased to 0.286 (SD = 0.083; n = 239) and 0.277 (SD = 0.049; n = 239) respectively. Thereby, the measured individual retention values of carbon disulfide show considerable interindividual differences. The respiratory uptake of carbon disulfide (mg CS2) proved significantly influenced by the amount of body fat estimated from skinfold thickness measurements. The respiratory elimination of carbon disulfide in the exhaled air can be described by means of a two-exponential decay.

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References

  1. Demus H (1964) On the reception, chemical transformation and excretion of carbon disulfide by the human body. Arch Gewerbepathol Gewerbehyg 20:507–511

  2. Djuric D (1967) Determination of carbon disulphide and its metabolites in biological material. In: Brieger H, Teisinger J (eds) Toxicology of carbon disulphide. Excerpta Medica, Amsterdam

  3. Durnin JUGA, Womersley J (1974) Body fat assessed from total body density and its estimation from skinfold thickness measurements on 481 men and women from 16 to 72 years. Br J Nutr 32:77–79

  4. Harashima S, Masuda Y (1962) Quantitative determination of absorption and elimination of carbon disulfide through different channels in the human body. Int Arch Gewerbepathol Gewerbehyg 19:263–269

  5. Herrmann G, Leuscke W, Vierhig J (1982) Zur inhalativen Aufnahme von Schwefelkohlenstoff. Z Ges Hyg 28; H 5:305–308

  6. Merlevede E (1951) De toxicologie van zwavelkoolstof, Sinte Catharine, Brugge

  7. Tahara Y (1961) Hygiene evaluation of work environment of rayon factories by carbon disulfide analysis of the expired air of workers. J Sci Labour 37:583

  8. Teisinger J (1954) Metabolism and detoxication of some industrial poisons. SZN, Praha, pp 106–110

  9. Teisinger J, Soucek B (1949) Absorption and elimination of carbon disulfide in man. J Ind Hyg 31:67–82

  10. Veulemans H, Masschelein R (1978) Experimental human exposure to toluene. Factors influencing the individual respiratory uptake and elimination. Int Arch Occup Environ Health 42:91–97

  11. Zielhuis LIZ (1980) De voortgang van het WGO-programma voor MAC-waarden. T Soc Geneesk 58,24:856–866

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Correspondence to J. Rosier.

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Rosier, J., Veulemans, H., Masschelein, R. et al. Experimental human exposure to carbon disulfide. Int. Arch Occup Environ Heath 59, 233–242 (1987). https://doi.org/10.1007/BF00377735

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Key words

  • Experimental exposure
  • Carbon disulfide
  • Respiratory uptake
  • Respiratory elimination
  • Workload