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Mechanism for bone disease found in inhabitants environmentally exposed to cadmium: decreased serum 1α, 25-dihydroxyvitamin D level

Summary

To investigate the mechanism for bone disease caused by exposure to cadmium serum samples were collected from 5 itai-itai disease patients, 36 Cd-exposed residents with renal tubular damage and 17 non-exposed individuals and analyzed for 1α,25-dihydroxyvitamin D[1α, 25(OH)2D], parathyroid hormone, β2-microglobulin, calcium and inorganic phosphorus. Measurement of percentage tubular reabsorption of phosphate (%TRP) were performed only on the Cd-exposed subjects. Serum 1α, 25(OH)2D], levels were lower in itai-itai disease patients and cadmium-exposed subjects with renal damage than in non-exposed subjects. Parathyroid hormone and β2-microglobulin concentrations in serum were higher in the Cd-exposed subjects. Decrease in serum 1α,25(OH)2D levels were closely related to serum concentrations of parathyroid hormone, β2-microglobulin and %TRP. This study suggests that cadmium-induced bone effects were mainly due to a disturbance in vitamin D and parathyroid hormone metabolism, which was caused by the cadmium-induced kidney damage.

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Correspondence to Kôji Nogawa.

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Nogawa, K., Tsuritani, I., Kido, T. et al. Mechanism for bone disease found in inhabitants environmentally exposed to cadmium: decreased serum 1α, 25-dihydroxyvitamin D level. Int. Arch Occup Environ Heath 59, 21–30 (1987). https://doi.org/10.1007/BF00377675

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Key words

  • Cadmium
  • Bone change
  • 1α,25(OH)2D
  • Renal damage