Archives of Dermatological Research

, Volume 284, Issue 4, pp 250–252 | Cite as

Induction of ICAM-1 expression by epidermal keratinocytes via a paracrine pathway possibly involving dermal dendritic cells

  • I. Bruynzeel
  • B. J. Nickoloff
  • E. M. H. van der Raaij
  • D. M. Boorsma
  • T. J. Stoof
  • R. Willemze
Short Communications

Key words

ICAM-1 Keratinocytes LPS TNF-α Dendritic cell 

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References

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    Barker JNWN, Mitra RS, Griffiths CEM, Dixit VM, Nickoloff BJ (1991) Keratinocytes as initiatiors of inflammation. Lancet 337: 211–214Google Scholar
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    Basham TY, Nickoloff BJ, Merigan TC, Morhenn VB (1984) Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. J Invest Dermatol 83: 88–92Google Scholar
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    Dustin ML, Singer KH, Tuck DT, Springer TA (1988) Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon γ and is mediated by intercellular adhesion molecule 1 (ICAM-1). J Exp Med 167: 1323–1340Google Scholar
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    Griffiths CEM, Voorhees JJ, Nickoloff BJ (1989) Characterization of intercellular adhesion molecule-1 and HLA-DR in normal and inflamed skin: modulation by interferon-gamma and tumor necrosis factor. J Am Acad Dermatol 20: 617–629Google Scholar
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    Nickoloff BJ, Griffiths CEM (1989) T lymphocytes and monocytes bind to keratinocytes in frozen sections of biopsy specimens of normal skin treated with gamma interferon. J Am Acad Dermatol 20: 736–743Google Scholar
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    Stoof TJ, Mitra RS, Sarma V, Dixit VM, Nickoloff BJ (1992) Keratinocyte activation following T-lymphocyte binding. J Invest Dermatol 98: 92–95Google Scholar
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    Streilein JW (1989) Antigen-presenting cells in the induction of contact hypersensitivity in mice: evidence that Langerhans cells are sufficient but not required. J Invest Dermatol 93: 443–448Google Scholar
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    Willis CM, Stephens CJM, Wilkinson JD (1991) Selective expression of immune-associated surface antigens by keratinocytes in irritant contact dermatitis. J Invest Dermatol 96: 505–511Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • I. Bruynzeel
    • 1
  • B. J. Nickoloff
    • 2
  • E. M. H. van der Raaij
    • 1
  • D. M. Boorsma
    • 1
  • T. J. Stoof
    • 1
  • R. Willemze
    • 1
  1. 1.Department of DermatologyFree University HospitalHV AmsterdamThe Netherlands
  2. 2.Department of Dermatology and PathologyUniversity of Michigan Medical SchoolAnn ArborUSA

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