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Cholecystokinin participates in the mediation of fever

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Cholecystokinin of the central nervous system participates in the pathogenesis of lipopolysaccharide- induced fever in rats, contributing mainly to the first phase rise of this fever. The mediatory role is connected to type- B receptors of cholecystokinin.

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  1. 1.

    Komaki G, Arimura A, Koves K (1992) Effect of intravenous injection of IL-1β on PGE2 levels in several train areas as determined by microdialysis. Am J Physiol 262: E246-E251

  2. 2.

    Milton AS (1989) Thermoregulatory actions of eicosanoids in the central nervous system with particular regard to the pathogenesis of fever. Ann N Y Acad Sci 559: 392–411

  3. 3.

    Mitchell D, Labum H, Cooper KE, Hellon RF, Cranston WI, Townsend Y (1986) Is prostaglandin E the neural mediator of the febrile response? The case against a proven obligatory role. Yale J Biol Med 59: 159–168

  4. 4.

    Simpson CW, Ruwe WD, Myers RD (1994) Prostaglandins and hypothalamic neurotransmitter receptors involved in hyperthermia: a critical evaluation. Neurosci Biobehav Rev 18: 1–20

  5. 5.

    Skames RC, Brown SK, Hull SS, McCracken JA (1981) Role of prostaglandin E in the biphasic fever response to endotoxin. J Exp Med 154: 1212–1224

  6. 6.

    Székely M, Szelényi Z (1982) The pathophysiology of fever in the neonate. Handb Exp Pharmacol 60: 479–528

  7. 7.

    Székely M, Sehic E, Menon V, Blatteis CM (1994) Apparent dissociation between lipopolysaccharide-induced release of prostaglandin E2 and fever in guinea pigs. In: Milton AS (ed) Temperature Regulation. Birkhäuser Verlag, Basel pp. 65–70

  8. 8.

    Szelényi Z, Barthó L, Székely M, Romanovsky AA (1994) Cholecystokinin octapeptide (CCK-8) injected into a cerebral ventricle induces a fever-like thermoregulatory response mediated by type-B CCK-receptors in the rat. Brain Res 638: 69–77

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Székely, M., Szelényi, Z. & Balaskó, M. Cholecystokinin participates in the mediation of fever. Pflugers Arch. 428, 671–673 (1994).

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  • cholecystokinin
  • L-365,260
  • neuropeptides
  • fever
  • lipopolysaccharide
  • thermoregulation