Comparative Haematology International

, Volume 4, Issue 2, pp 108–113 | Cite as

Suppression of erythroid progenitors in ponies infected with equine infectious anaemia virus

  • C. J. Swardson
  • Gary J. Kociba
Original Article

Abstract

Six clinically normal ponies were infected intravenously with equine infectious anaemia virus (EIAV) to determine the effect of EIAV on numbers of erythroid, granulocyte/monocyte and fibroblastic progenitors in the bone marrow. Bone marrow progenitor assays were performed at weeks 1, 2, 3, 4 and 8 postinfection. The late erythroid progenitors, colony-forming units-erythroid (CFU-E), were suppressed at each time point postinfection with the maximal suppression occurring at week 2 postinfection. The maximal suppression corresponded to the peak of plasma virus concentration. The maximal suppression of the early erythroid progenitors, burst-forming units-erythroid (BFU-E), also occurred at week 2 postinfection. Removal of adherent cells from the bone marrow mononuclear cells (BMMC) abrogated the suppression. Neither granulocyte/monocyte progenitors (CFU-GM) nor fibroblastic progenitors (CFU-F) were affected by EIAV infection.

Keywords

Anaemia Equine Haematopoiesis Lentivirus 
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Copyright information

© Springer-Verlag London Limited 1994

Authors and Affiliations

  • C. J. Swardson
    • 1
  • Gary J. Kociba
    • 1
  1. 1.Department of Veterinary PathobiologyThe Ohio State UniversityColumbusUSA

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