Current Genetics

, Volume 13, Issue 2, pp 129–135

Nuclear omnipotent suppressors of premature termination codons in mitochondrial genes affect the 37S mitoribosomal subunit

  • Magdalena Boguta
  • Maria Mieszczak
  • Wlodzimierz Zagórski
Original Articles

Summary

nam3 and R705, yeast nuclear omnipotent suppressors of mitochondrial mit mutations, reverse the superimposed spectrum of trans-recessive splicing defects by affecting the protein composition of the small mitoribosomal subunit. Analysis of the suppressor's interaction suggests that suppression results from mutations in the mitoribosomal polypeptides. These data indicate an obligatory connection between mitoribosome function and splicing of introns bI2, bI4 and aI1 in yeast mitochondria.

Key words

Mitochondrial ribosomes Suppressor nam mutants 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Magdalena Boguta
    • 1
  • Maria Mieszczak
    • 1
  • Wlodzimierz Zagórski
    • 1
  1. 1.Institute of Biochemistry and BiophysicsPolish Academy of SciencesWarsawPoland

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