Adrenal 17-Hydroxycorticosteroid secretion in response to cyanide anoxia

  • T. Suzuki
  • K. Yamashita
  • K. Hirai
  • K. -I. Kurouji
  • H. Yoshio
Article
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Summary

Adrenal venous blood samples were collected from conscious dogs and analysed for 17-hydroxycorticosteroids (17-OHCS) and catechol amines. Potassium cyanide was administered subcutaneously in doses of 1.0–4.0 mg/kg. The pre-injection secretion rates of 17-OHCS per gland were 0.02–0.26 μg/kg/min. In all the experiments, the 17-OHCS secretion rates increased after cyanide injection to maximal values of 0.60–1.55 μg/kg/min. After injection of 1.0–3.0 mg/kg cyanide, the adrenal medullary secretion rates remained unchanged. Dogs given 4.0 mg/kg cyanide had elevated adrenal medullary secretion rates when anoxic symptoms, such as convulsions, were manifested. The present findings suggest that adrenal cortical response is more sensitive than adrenal medullary response to cyanide anoxia.

Keywords

Potassium Cyanide Human Physiology Catechol Amine Present Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Nebennierenvenenblut wurde an nicht narkotisierten und nicht gefesselten Hunden entnommen und der Gehalt an 17-Hydroxycorticosteroiden (17-OHCS) und Catechinaminen abgeschätzt. KCN wurde in Dosen von 1,0–4,0 mg pro Kilogramm Körpergewicht subcutan eingespritzt. Die Sekretionsgeschwindigkeit von 17-OHCS vor der Injektion betrug 0,02–0,26 μg pro Minute und Kilogramm Körpergewicht. Nach der Injektion war bei allen Dosierungen die Sekretionsgeschwindigkeit stark beschleunigt. Die höchsten Werte betrugen 0,60–1,55 μg pro Minute und Kilogramm. KCN in Dosen von 1,0–3,0 mg pro Kilogramm rief keine Hypersekretion des Nebennierenmarks, dagegen in der Dose von 4,0 mg pro Kilogramm eine ausgiebige Vergrößerung der Sekretionsgeschwindigkeit des Nebennierenmarks hervor. In den vorliegenden Experimenten finden wir demnach einen Hinweis darauf, daß der Sekretionsmechanismus von Nebennierenrinde gegen der Blausäurevergiftung empfindlicher als der von Nebennierenmark ist.

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Copyright information

© Springer-Verlag 1965

Authors and Affiliations

  • T. Suzuki
    • 1
  • K. Yamashita
    • 1
  • K. Hirai
    • 1
  • K. -I. Kurouji
    • 1
  • H. Yoshio
    • 1
  1. 1.Department of PhysiologyNagasaki University School of MedicineNagasakiJapan

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