The effect of veratridine on internally perfused giant axons

  • Hans Meves
Article
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Summary

The effect of adding small amounts of veratridine to the internal fluid of perfused squid giant axons was investigated. 2×10−5 g/ml veratridine applied internally caused a transient depolarization of 50 mV whereas 8×10−6 g/ml had little effect on the resting potential. The spike was followed by a long lasting after-depolarization of up to 19 mV amplitude which decayed in a non-exponential manner. Repetitive activity following a single brief shock was observed. Repetitive stimulation (4/sec) produced non-linear addition of the after-depolarizations. The effects of internally applied veratridine were fully reversible. The findings are compared with the effects of externally applied veratridine on squid axons.

Keywords

Human Physiology Repetitive Stimulation Giant Axon Internal Fluid Veratridine 
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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • Hans Meves
    • 1
    • 2
    • 3
  1. 1.Laboratory of the Marine Biological AssociationPlymouth
  2. 2.Physiological LaboratoryUniversity of CambridgeUK
  3. 3.I. Physiologisches Institut der Universität des Saarlandes665 Homburg/Saar

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