Zur Wirkung des Acetylcholins auf die Atmung

III. Mitteilung: Wirkung bei Injektion in die A. carotis interna
  • Wolfgang Wiemer
Article
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Summary

Acetylcholine in doses from 0,5 to 60 μg was injected into the internal carotid artery of rabbits via the (distally ligated) external carotid artery.

In animals with denervated carotid sinuses small doses either diminished (even to the degree of apnea) or, in other animals, augmented the depth of respiration. Higher doses regularly caused a combined reaction consisting of a short initial depression of respiration (even apnea), followed by hyperpnea. The rate of respiration changed inconsistantly and, usually, insignificantly. These results are interpreted as excitation and interaction of two different central mechanisms influencing respiration in a contrary way. — Blood pressure was mostly lowered, occasionally raised. Vagotomy modified, but did not abolish these reactions.

In animals with intact carotid sinus, excitation of carotid chemoreceptors was revealed by an additional increase of rate and depth of respiration which could be abolished by carotid denervation. However, these chemoreceptor effects usually interfered with the above described central effects, the threshold probably being about the same.

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Copyright information

© Springer-Verlag 1962

Authors and Affiliations

  • Wolfgang Wiemer
    • 1
  1. 1.Aus dem Physiologischen Institut der Universität MünchenGermany

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