Roux's archives of developmental biology

, Volume 200, Issue 4, pp 234–236 | Cite as

Nerve cell production in Hydra is deregulated by tumour-promoting phorbol ester

  • Valerie Greger
  • Stefan Berking
Short Communication


The tumour-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) interfers with nerve cell production in Hydra when applied to the animals' culture medium. Precursor cells exposed to 0.2 nM TPA during the first half of their S-phase are prevented from differentiating into nerve cells. Precursor cells which start their S-phase following a treatment with TPA give rise to nerve cells. The frequency is higher than in untreated control animals.

Key words

Hydra Nerve cells Differentiation Tumour-promoting phorbol esters 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Valerie Greger
    • 1
  • Stefan Berking
    • 1
  1. 1.Zoologisches Institut der Universität zu KölnKölnFederal Republic of Germany

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