Skeletal Radiology

, Volume 14, Issue 1, pp 10–19 | Cite as

Red-yellow marrow conversion: Its effect on the location of some solitary bone lesions

  • Morrie E. Kricun


The location of red marrow related bone lesions is dependent upon the distribution of red marrow. It is altered by the normal conversion of red marrow to yellow (fat) marrow and by the reconversion of yellow marrow to red marrow caused by marrow infiltrating disorders or marrow stress disorders.

Key words

Marrow Marrow conversion Marrow lesions Tumors Infection Bone infarction 


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  1. 1.
    Aegerter E, Kirkpatrick JA Jr (1975) Orthopedic diseases. Saunders, Philadelphia, p 587Google Scholar
  2. 2.
    Alavi A, Bond JP, Kuhl DE, Creech RH (1974) Scan detection of bone marrow infarcts in sickle cell disorders. J Nucl Med 15:1003Google Scholar
  3. 3.
    Batson OV (1940) The function of the vertebral veins and their role in the spread of metastases. Ann Surg 112:138Google Scholar
  4. 4.
    Bohrer SP (1970) Acute long bone diaphyseal infarcts in sickle cell disease. Br J Radiol 43:685Google Scholar
  5. 5.
    Brookes M (1971) The blood supply of bone. Butterworth, London, pp 22, 136, 137Google Scholar
  6. 6.
    Collins VP, Loeffler RK, Tivey H (1956) Observations on growth rates of human tumors. AJR 76:988Google Scholar
  7. 7.
    Custer RP (1932) Studies on the structure and function of bone marrow. J Lab Clin Med 17:951Google Scholar
  8. 8.
    Custer RP, Ahlfeldt FE (1932) Studies on the structure and function of bone marrow. J Lab Clin Med 17:960Google Scholar
  9. 9.
    Dahlin DC, Coventry MD, Scanlon PW (1961) Ewing's sarcoma. A critical analysis of 165 cases. J Bone Joint Surg [Am] 43:185Google Scholar
  10. 10.
    Diggs LW (1967) Bone and joint lesions in sickle-cell disease. Clin Orthop 52:119Google Scholar
  11. 11.
    Emery JL, Follett GF (1964) Regression of bone-marrow haemopoiesis from the terminal digits in the foetus and infant. Br J Haematol 10:485Google Scholar
  12. 12.
    Geschickter CF, Copeland MM (1949) Tumors of bone. Lippincott, PhiladelphiaGoogle Scholar
  13. 13.
    Hashimoto M (1960) The distribution of active marrow in the bones of normal adult. Kyushu J Med Sci 11:103Google Scholar
  14. 14.
    Hashimoto M (1962) Pathology of bone marrow. Acta Haematol (Basel) 27:193Google Scholar
  15. 15.
    Huggins C, Blocksom BH Jr (1936) Changes in outlying bone marrow accompanying a local increase of temperature within physiological limits. J Exp Med 64:253Google Scholar
  16. 16.
    Huggins C, Blocksom BH Jr, Noonan WJ (1936) Temperature conditions in the bone marrow of rabbit, pigeon, and albino rat. Am J Physiol 115:395Google Scholar
  17. 17.
    Huggins C, Noonan WJ (1936) An increase in reticulo-endothelial cells in outlying bone marrow consequent upon a local increase in temperature. J Exp Med 64:275Google Scholar
  18. 18.
    Jacobson HG, Poppel MH, Shapiro JH, Grossberger S (1958) The vertebral pedicle sign. AJR 80:817Google Scholar
  19. 19.
    Johnston AD (1970) Pathology of metastatic tumors in bone. Clin Orthop 73:8Google Scholar
  20. 20.
    Krishnamurthy GT, Tubis M, Hiss J, Blahd WH (1977) Distribution pattern of metastatic bone disease. JAMA 237:2504Google Scholar
  21. 21.
    Miller TR, Nicholson JT (1971) End results in reticulum cell sarcoma of bone treated by bacterial toxin therapy alone of combined with surgery and/or radiotherapy (47 cases) or with concurrent infection (5 cases). Cancer 27: 524Google Scholar
  22. 22.
    Neumann E (1882) Das Gesetz der Verbreitung des gelben und roten Markes in den Extremitätenknochen. Centralblatt f d med Wissenschaften 20:321Google Scholar
  23. 23.
    Nixon GW (1978) Hematogenous osteomyelitis of metaphyseal-equivalent locations. AJR 130:123Google Scholar
  24. 24.
    Oehlbeck LWF, Robscheit-Robbins FS, Whipple GH (1932) Marrow hyperplasia and hemoglobin reserve in experimental anemia due to bleeding. J Exp Med 56:425Google Scholar
  25. 25.
    Parker F Jr, Jackson H Jr (1939) Primary reticulum cell sarcoma of bone. Surg Gynecol Obstet 68:45–53Google Scholar
  26. 26.
    Paul LW, Pohle EA (1940) Solitary myeloma of bone. Radiology 35:651Google Scholar
  27. 27.
    Piney A (1922) The anatomy of the bone marrow. Br Med J II:792Google Scholar
  28. 28.
    Piney A (1922) Metastases in bone marrow. J Pathol Bacteriol 25:140Google Scholar
  29. 29.
    Putschar W. Personal communicationGoogle Scholar
  30. 30.
    Rang M (1969) The growth plate and its disorders Rang M (ed) Williams and Wilkins, Baltimore, p 78Google Scholar
  31. 31.
    Ridings Gr (1964) Ewing's tumor. Radiol Clin North Am 2:315Google Scholar
  32. 32.
    Sabin FR (1928) Bone marrow. Physiol Rev 8:191Google Scholar
  33. 33.
    Shillingford JP (1950) The red bone marrow in heart failure. J Clin Pathol 3:24Google Scholar
  34. 34.
    Sirry A (1951) The pseudocystic triangle in the normal os calcis. Acta Radiol 36:516Google Scholar
  35. 35.
    Steinbach HL, Jergesen F, Gilfillan RS, Petrakis NL (1957) Osseous phebography. Surg Gynecol Obstet 104:215Google Scholar
  36. 36.
    Trueta J (1959) The three types of acute haematogenous osteomyelitis. J Bone Joint Surg [Br] 41:671Google Scholar
  37. 37.
    Trueta J (1968) Studies of the development and decay of the human frame. Saunders, Philadelphia, Chapter 30, p 258Google Scholar
  38. 38.
    Turner JW, Jaffe HL (1940) Metastatic neoplasms. A clinical and roentgenological study of involvement of skeleton and lungs. AJR 43:479Google Scholar
  39. 39.
    Warwick R, Williams PL (1973) Gray's anatomy. Saunders, Philadelphia, p 49Google Scholar
  40. 40.
    Weiss L (1965) The structure of bone marrow. J Morphol 117:467Google Scholar
  41. 41.
    Whitby LEH, Britton CJC (1969) Disorders of the blood, 10th edn. Grune and Stratton, New York, pp 7, 8Google Scholar
  42. 42.
    Wiley AM, Trueta J (1959) The vascular anatomy of the spine and its relationship to pyogenic vertebral osteomyelitis. J Bone Joint Surg [Br] 41:794Google Scholar
  43. 43.
    Wintrobe MM (1981) Clinical hematology, 8th edn. Lea and Febiger, Philadelphia, p 48Google Scholar
  44. 44.
    Zadek I (1938) Acute osteomyelitis of the long bones of adults. Arch Surg 37:531Google Scholar

Copyright information

© International Skeletal Society 1985

Authors and Affiliations

  • Morrie E. Kricun
    • 1
  1. 1.Department of RadiologyHospital of the University of PennsylvaniaPhiladelphiaUSA

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