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Molecular Biology Reports

, Volume 2, Issue 2, pp 151–157 | Cite as

Utilization of in vivo alkylated metabolites as a possible cause of increased sensitivity of tumor cells to alkylating agents

  • M. I. Lerman
  • O. Yu. Abakumova
  • N. G. Kutcenko
  • I. S. Sokolova
  • L. B. Gorbacheva
  • A. M. Serebryannyi
Article

Abstract

In this paper it is shown that the cells of hepatoma 22a utilize alkylated metabolites, which are formed in vivo after a single injection of MNU. These antimetabolites are efficiently incorporated into tumor DNA, RNA and proteins.

Keywords

Tumor Cell Single Injection Alkylating Agent Alkylated Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MNU

N-methyl-N-nitroso-urea

TCA

trichloroacetic acid

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References

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Copyright information

© D. Reidel Publishing Company 1975

Authors and Affiliations

  • M. I. Lerman
    • 1
  • O. Yu. Abakumova
    • 1
  • N. G. Kutcenko
    • 1
  • I. S. Sokolova
    • 2
  • L. B. Gorbacheva
    • 2
  • A. M. Serebryannyi
    • 2
  1. 1.Institute of Biological and Medical ChemistryAcademy of Medical Sciences of U.S.S.R.MoscowUSSR
  2. 2.Institute of Chemical PhysicsAcademy of Sciences of U.S.S.R.MoscowUSSR

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