Current Genetics

, Volume 11, Issue 4, pp 295–301 | Cite as

A mitochondrial frameshift-suppressor (+) of the yeast S. cerevisiae maps in the mitochondrial 15S rRNA locus

  • Brigitte Weiss-Brummer
  • Hajime Sakai
  • Fritz Kaudewitz


The first case of a +1 “extrageneic” frameshift suppressor (MF1), mapping in the yeast mitochondrial 15S rRNA gene is reported. The suppressor was identified by genetic analyses in a leaky mitochondrial oxi1 frameshift mutant and the respective wild-type strain 777-3A of the yeast S. cerevisiae. This is in accordance with the finding that all mitochondrial frameshift mutants isolated from this strain tend to be leaky to a variable degree. MF1 does not suppress known nonsense mutations created by a direct basepair exchange in strain 777-3A. These mutants exhibit a non-leaky phenotype (Weiss-Brummer et al. 1984).

Key words

Yeast Mitochondrial Frameshift-Suppression 15S rRNA 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Brigitte Weiss-Brummer
    • 1
  • Hajime Sakai
    • 1
  • Fritz Kaudewitz
    • 1
  1. 1.Institut für Genetik und Mikrobiologie, Lehrstuhl für GenetikUniversität MünchenMünchen 19Germany

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