Archives of Toxicology

, Volume 52, Issue 2, pp 123–133 | Cite as

Inhalation pharmacokinetics based on gas uptake studies

IV. The endogenous production of volatile compounds
  • J. G. Filser
  • H. M. Bolt
Original Investigations


A pharmacokinetic description of production, distribution and metabolism of endogenous volatile compounds is presented. This description uses the “gas uptake model” of a closed recirculated atmosphere in which experimental animals are exposed. As an example, the production rates of acetone, under different conditions of stimulation by xenobiotics, are calculated from published experimental data.

The theoretical descriptions may serve as a basis for treating the problem of hydrocarbon exhalation in toxicological experiments with compounds eliciting lipid peroxidation.

Key words

Pharmacokinetics Gas uptake Acetone Hydrocarbons 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • J. G. Filser
    • 1
  • H. M. Bolt
    • 1
  1. 1.Abteilung für Toxikologie, Pharmakologisches Institut der UniversitätMainz 1Germany

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