Inhalation pharmacokinetics based on gas uptake studies
A pharmacokinetic description of production, distribution and metabolism of endogenous volatile compounds is presented. This description uses the “gas uptake model” of a closed recirculated atmosphere in which experimental animals are exposed. As an example, the production rates of acetone, under different conditions of stimulation by xenobiotics, are calculated from published experimental data.
The theoretical descriptions may serve as a basis for treating the problem of hydrocarbon exhalation in toxicological experiments with compounds eliciting lipid peroxidation.
Key wordsPharmacokinetics Gas uptake Acetone Hydrocarbons
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- Andersen ME (1981) A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: analysis at steady state. Toxicol Appl Pharmacol 60: 509–526Google Scholar
- Anderson ME, Gargas ML, Jones RA, Jenkins LJ (1980) Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements. Toxicol Appl Pharmacol 54: 100–116Google Scholar
- Bolt HM, Filser JG, Buchter A (1981) Inhalation pharmacokinetics based on gas uptake studies. III. A pharmacokinetic assessment in man of “peak concentrations” of vinyl chloride. Arch Toxicol 48: 213–218Google Scholar
- Dillard CJ, Dumelin EE, Tappel AL (1977) Effect of dietary vitamin E on expiration of pentane and ethane by the rat. Lipids 12: 109–114Google Scholar
- Filser JG, Bolt HM (1979) Pharmacokinetics of halogenated ethylenes in the rat. Arch Toxicol 42: 123–136Google Scholar
- Filser JG, Bolt HM (1980) Characteristics of haloethylene-induced acetonemia in rats. Arch Toxicol 45: 109–116Google Scholar
- Filser JG, Bolt HM (1981) Inhalation pharmacokinetics based on gas uptake studies. I. Improvement of kinetic models. Arch Toxicol 47: 279–292Google Scholar
- Filser JG, Jung P, Bolt HM (1982) Increased acetone exhalation induced by metabolites of halogenated C1 and C2 compounds. Arch Toxicol 49: 107–116Google Scholar
- Filser JG, Bolt HM, Muliawan H, Kappus H (1983) Quantitative evaluation of ethane and n-pentane as indicators of lipid peroxidation in vivo. Arch Toxicol 52: 135–147Google Scholar
- Frank H, Hintze T, Bimboes D, Remmer H (1980) Monitoring lipid peroxidation by breath analysis: endogenous hydrocarbons and their metabolic elimination. Toxicol Appl Pharmacol 56: 337–344Google Scholar
- Hallier E, Filser JG, Bolt HM (1981) Inhalation pharmacokinetics based on gas uptake studies. II. Pharmacokinetics of acetone in rats. Arch Toxicol 47: 293–304Google Scholar
- Riely CA, Cohen G, Lieberman M (1974) Ethane evolution: a new index of lipid peroxidation. Science 183: 208–210Google Scholar
- Robinson AM, Williamson DH (1980) Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol Rev 60: 143–187Google Scholar