Mammalian Genome

, Volume 6, Issue 9, pp 636–639

The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination

  • H. Klungland
  • D. I. Vage
  • L. Gomez-Raya
  • S. Adalsteinsson
  • S. Lien
Original Contributions

Abstract

The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.

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Copyright information

© Springer-Verlag New York Inc 1995

Authors and Affiliations

  • H. Klungland
    • 1
  • D. I. Vage
    • 1
  • L. Gomez-Raya
    • 1
  • S. Adalsteinsson
    • 2
  • S. Lien
    • 1
  1. 1.Department of Animal ScienceAgricultural University of NorwayÅsNorway
  2. 2.The Nordic Gene Bank for Farm Animals, Department of Animal ScienceAgricultural University of NorwayÅsNorway

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