Mammalian Genome

, Volume 6, Issue 9, pp 636–639 | Cite as

The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination

  • H. Klungland
  • D. I. Vage
  • L. Gomez-Raya
  • S. Adalsteinsson
  • S. Lien
Original Contributions


The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.


Point Mutation Frameshift Mutation Dominant Allele Major Function Color Information 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag New York Inc 1995

Authors and Affiliations

  • H. Klungland
    • 1
  • D. I. Vage
    • 1
  • L. Gomez-Raya
    • 1
  • S. Adalsteinsson
    • 2
  • S. Lien
    • 1
  1. 1.Department of Animal ScienceAgricultural University of NorwayÅsNorway
  2. 2.The Nordic Gene Bank for Farm Animals, Department of Animal ScienceAgricultural University of NorwayÅsNorway

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