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Mammalian Genome

, Volume 5, Issue 3, pp 167–170 | Cite as

Mapping of an insulin-dependent diabetes locus, Idd9, in NOD mice to Chromosome 4

  • N. R. Rodrigues
  • R. J. Cornall
  • P. Chandler
  • E. Simpson
  • L. S. Wicker
  • L. B. Peterson
  • J. A. Todd
Short Communications

Keywords

Diabetes Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abbott, C., Blank, R., Eppig, J. Friedman, J., Huppi, K., Jackson, I., Mock, B., Stoye, J., Wiseman, R. (1992). Mouse Chromosome 4. Mamalian Genome 3(Suppl), S55-S64.Google Scholar
  2. Bain, S.C., Prins, J.B., Hearne, C.M., Rodrigues, N.R., Rowe, B.R., Pritchard, L.E., Ritchie, R.J., Hall, J. R.S., Undlien, D.E., Ronningen, K.S., Dunger, D.B., Barnett, A.H., Todd, J.A. (1992). Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nature Genet. 2, 212–215.Google Scholar
  3. Cornall, R.J., Prins, J.-B., Todd, J.A., Pressey, A., DeLarato, N.H., Wicker, L.S., Peterson, L.B. (1991). Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1, Nature 353, 262–265.Google Scholar
  4. Ghosh, S., Palmer, S., Rodrigues, N., Cordell, H., Hearne, C., Cornall, R., Prins, J.-B., McShane, P., Lathrop, G., Peterson, L., Wicker, L., Todd, J. (1993). Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genet. 4, 404–409.Google Scholar
  5. Harada, M., Makino, S. (1984). Promotion of spontaneous diabetes in nonobese diabetes-prone mice by cyclophosphamide. Diabetologia 27, 604–606.Google Scholar
  6. Hattori, M., Buse, J.B., Jackson, R.A., Glimcher, L., Dorf, M.E., Minami, M., Makino, S., Moriwaki, K., Kuzuya, H., Imura, H., Strauss, W.M., Seidman, J.G., Eisenbarth, G.S. (1986). The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 231, 733–735.Google Scholar
  7. Hearne, C.M., McAleer, M.A., Love, J.M., Aitman, T.J., Cornall, R.J., Ghosh, S., Knight, A.M., Prins, J.-B., Todd, J.A. (1991). Additional microsatellite markers for mouse genome mapping. Mammalian Genome 1, 273–282.Google Scholar
  8. Jacob, H., Petersson, A., Wilson, D., Mao, Y., Lernmark, A., Lander, E. (1992). Genetic dissection of autoimmune type 1 diabetes in the BB rat. Nature Genet. 2, 56–60.Google Scholar
  9. Julier, C., Hyer, R.N., Davies, J., Merlin, F., Soularu, P., Briant, L., Cathelineau, G., Deschamps, I., Rotter, J.I., Froguel, P., Boitard, C., Bell, J.I., Lathrop, G.M. (1991). Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature 354, 155–159.Google Scholar
  10. Kikutano, H., Makino, S. (1992). The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51, 285–322.Google Scholar
  11. Ott, J. (1985). Analysis of Human Genetic Linkage. Baltimore: Johns Hopkins University Press.Google Scholar
  12. Prochazka, M., Leiter, E.H., Serreze, D.V., Coleman, D.L. (1987) Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice. Science 237, 286–289.Google Scholar
  13. Risch, N. (1987). Assessing the role of HLA-linked and unlinked determinants of disease. Am. J. Hum. Genet. 40, 001–014.Google Scholar
  14. Risch, N. (1991). A note on multiple testing procedures in linkage analysis. Am. J. Hum. Genet. 48, 1058–1064.Google Scholar
  15. Risch, N., Ghosh, S., Todd, J.A. (1993). Statistical evaluation of multiple locus linkage data in experimental species and relevance to human studies: application to murine and human IDDM. Am. J. Hum. Genet. 53, 702–714.Google Scholar
  16. Todd, J. A., Bain, S.C. (1992). A practical approach to the identification of susceptibility genes for type 1 diabetes. Diabetes 41, 1029–1034.Google Scholar
  17. Todd, J.A., Aitman, T.J., Cornall, R.J., Ghosh, S., Hall, J.R.S., Hearne, C.M., Knight, A.M., Love, J.M., McAleer, M.A., Prins, J.-B., Rodrigues, N., Lathrop, G.M., Pressey, A., DeLarato, N., Peterson, L.B., Wicker, L.S. (1991). Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Nature 351, 542–547.Google Scholar
  18. Wicker, L.S., Miller, B.J., Coker, L.Z., McNally, S.E., Scott, S., Mullen, Y., Appel, J.C. (1987). Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse. J. Exp. Med. 165, 1639–1654.Google Scholar
  19. Wicker, L.S., Appel, M.C., Dotta, F., Pressey, A., Miller, B.J., DeLarato, N.H., Fischer, P.A., Boltz, R.C., Peterson, L.B. (1992). Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J. Exp. Med. 176, 67–77.Google Scholar
  20. Yasunami, R., Bach, J.-F. (1988). Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur. J. Immunol. 18, 481–484.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1994

Authors and Affiliations

  • N. R. Rodrigues
    • 1
  • R. J. Cornall
    • 1
  • P. Chandler
    • 3
  • E. Simpson
    • 3
  • L. S. Wicker
    • 2
  • L. B. Peterson
    • 4
  • J. A. Todd
    • 1
  1. 1.Nuffield Department of SurgeryUniversity of Oxford, John Radcliffe HospitalOxfordUK
  2. 2.Autoimmune Discases Research, Merck Research LaboratoriesRahwayUSA
  3. 3.Transplantation Biology UnitClinical Research CentreHarrowUK
  4. 4.Merck Research LaboratoriesDepartment of Cellular and Molecular PharmacologyRahwayUSA

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